Browsing College of Science by Author "Crowley, Peter B."
Now showing items 1-4 of 4
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Calixarene-mediated assembly of a small antifungal protein
Alex, Jimi M.; Rennie, Martin L.; Engilberge, Sylvain; Lehoczki, Gábor; Dorottya, Hajdu; Fizil, Ádám; Batta, Gyula; Crowley, Peter B. (International Union of Crystallography, 2019-02-05)Synthetic macrocycles such as calixarenes and cucurbiturils are increasingly applied as mediators of protein assembly and crystallization. The macrocycle can facilitate assembly by providing a surface on which two or more ... -
Supramolecular stacking in a high Z′ calix[8]arene–porphyrin assembly
Alex, Jimi M.; McArdle, Patrick; Crowley, Peter B. (Royal Society of Chemistry, 2019-11-15)A co-crystal structure of sulfonato-calix[8]arene (sclx8) and trimethylanilinium-porphyrin (tmap) at 1.0 Å resolution is reported. The oppositely charged macrocycles formed an alternating stacked assembly. Crystal packing ... -
A thermodynamic model of auto-regulated protein assembly by a supramolecular scaffold
Rennie, Martin L.; Crowley, Peter B. (Wiley, 2019-03-12)Ligand-mediated regulation of protein assembly occurs frequently in different cellular contexts. Auto-regulated assembly, where a ligand acts as its own competitive inhibitor, provides a mechanism for exquisite control of ... -
Tuning protein frameworks via auxiliary supramolecular interactions
Engilberge, Sylvain; Rennie, Martin L.; Dumon, Elise; Crowley, Peter B. (American Chemical Society, 2019-09-06)Protein crystals with their precise, periodic array of functional building blocks have potential applications in biomaterials, sensing, and catalysis. This paper describes how a highly porous crystalline framework of a ...