Browsing by Subject "ischemia-reperfusion injury"

Now showing items 1-11 of 11

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      O' Croinin, Donall; Ni Chonghaile, Martina; Higgins, Brendan; Laffey, John G (Springer Nature, 2004-01-01)
      Current protective lung ventilation strategies commonly involve hypercapnia. This approach has resulted in an increase in the clinical acceptability of elevated carbon dioxide tension, with hypoventilation and hypercapnia ...

    • Caspases as therapeutic targets 

      Howley, B.; Fearnhead, H.O. (Wiley-Blackwell, 2008-09-01)
      The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; ...

    • Dendritic cells facilitate accumulation of il-17t cells in the kidney following acute renal obstruction 

      Dong, Xiangyang; Bachman, Lori A.; Miller, Melinda N.; Nath, Karl A.; Griffin, Matthew D. (Elsevier BV, 2008-11-01)
      Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) ...

    • Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease 

      Reeve, Janice L. V.; Duffy, Angela M.; O'Brien, Timothy; Samali, Afshin (Wiley-Blackwell, 2005-07-01)
      Cardiovascular disease is a leading cause of death worldwide. Loss of function or death of cardiomyocytes is a major contributing factor to these diseases. Cell death in conditions such as heart failure and myocardial ...

    • First responders: understanding monocyte-lineage traffic in the acutely injured kidney 

      Swaminathan, Sundararaman; Griffin, Matthew D. (Elsevier BV, 2008-12-01)
      Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between ...

    • Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an nf- b dependent mechanism 

      O'Toole, D; Hassett, P; Contreras, M; Higgins, B D; McKeown, S T W; McAuley, D F; O'Brien, T; Laffey, J G (BMJ, 2009-07-16)
      Background: Hypercapnic acidosis exerts protective effects in acute lung injury but may also slow cellular repair. These effects may be mediated via inhibition of nuclear factor-kappa B (NF-kappa B), a pivotal transcriptional ...

    • Inflammation in aki: current understanding, key questions, and knowledge gaps 

      Rabb, H.; Griffin, M. D.; McKay, D. B.; Swaminathan, S.; Pickkers, P.; Rosner, M. H.; Kellum, J. A.; Ronco, C.; , (American Society of Nephrology (ASN), 2015-11-11)
      Inflammation is a complex biologic response that is essential for eliminating microbial pathogens and repairing tissue after injury. AKI associates with intrarenal and systemic inflammation; thus, improved understanding ...

    • Losing heart: the role of apoptosis in heart disease--a novel therapeutic target? 

      GILL, C. (FASEB, 2002-02-01)
      Cardiovascular disease is a leading cause of death worldwide. In recent years it has emerged that loss of myocardial cells may be a major pathogenic factor. Cell death can occur in a destructive, uncontrolled manner via ...

    • Mesenchymal stem cell inhibition of t-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin e2 via the ep4 receptor 

      Duffy, Michelle M.; Pindjakova, Jana; Hanley, Shirley A.; McCarthy, Cathal; Weidhofer, Gudrun A.; Sweeney, Eva M.; English, Karen; Shaw, Georgina; Murphy, J. Mary; Barry, Frank P.; Mahon, Bernard P.; Belton, Orina; Ceredig, Rhodri; Griffin, Matthew D. (Wiley-Blackwell, 2011-08-30)
      Mesenchymal stem cells (MSCs) inhibit T-cell activation and proliferation but their effects on individual T-cell-effector pathways and on memory versus naive T cells remain unclear. MSC influence on the differentiation of ...

    • N-acetylcysteine protects striated muscle in a model of compartment syndrome 

      Kearns, Stephen R.; O’Briain, David E.; Sheehan, Katherine M.; Kelly, Cathal; Bouchier-Hayes, David (Springer Nature, 2010-03-23)
      Background To avoid ischemic necrosis, compartment syndrome is a surgical emergency treated with decompression once identified. A potentially lethal, oxidant-driven reperfusion injury occurs after decompression. N-acetylcysteine ...

    • The renal mononuclear phagocytic system 

      Nelson, P. J.; Rees, A. J.; Griffin, M. D.; Hughes, J.; Kurts, C.; Duffield, J. (American Society of Nephrology (ASN), 2011-12-01)
      The renal mononuclear phagocytic system, conventionally composed of macrophages (Mempty set) and dendritic cells (DCs), plays a central role in health and disease of the kidney. Overlapping definitions of renal DCs and M, ...