Browsing by Subject "Surgery"
Now showing items 1-20 of 41
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Advances in the management and treatment algorithms for anterior shoulder instability
(NUI Galway, 2022-04-28)Anterior shoulder instability is a common clinical problem, with a reported incidence ranging from 8 to 25 per 100,000 person years in the general population, with higher rates seen 1-3 in athletic populations. However, ... -
Analysis of cytokine expression in breast cancer
(2014-10-29)Introduction: It has long been recognized that cancer develops in sites of chronic inflammation. Tumours seem to seize molecular pathways seen in wound healing and the inflammatory response and as a consequence appear as ... -
Breast cancer research output, 1945-2008: a bibliometric and density-equalizing analysis
(BioMed Central, 2010-12)Introduction: Breast cancer is the most common form of cancer among women, with an estimated 194,280 new cases diagnosed in the United States in 2009 alone. The primary aim of this work was to provide an in-depth evaluation ... -
Career choices of today's medical students: where does surgery rank?
(Springer, 2013-11-15)The national junior doctor recruitment crisis prompts an appraisal of medical student attitudes to different career pathways. The purpose of this study was to perform a national review of surgical career intentions of Irish ... -
Cartilage repair in a rabbit model: Development of a novel subchondral defect and assessment of early cartilage repair using a rabbit mesenchymal stem cell seeded scaffold
(2018-02-14)Purpose: To develop a subchondral defect in a rabbit model and assess cartilage repair using a mesenchymal stem cell-seeded scaffold. Materials and Methods: To achieve this goal, a bovine explant model and two pilot ... -
A clinical evaluation of remote ischaemic preconditioning for organ protection
(2016-05-24)Periprocedural complications are an issue for patients with cardiovascular disease. Remote ischaemic preconditioning (RIPC) may offer periprocedural organ protection. Although the proof of concept data underpinning RIPC ... -
A comparison of the teamwork attitudes and knowledge of Irish surgeons and U.S Naval aviators.
(Elsevier, 2012-10)Poor teamwork skills are contributors to poor performance and mishaps in high risk work settings, including the operating theatre. A questionnaire was used to assess the attitudes towards, and knowledge of, Irish surgeons ... -
Current and potential diagnostic modalities in the detection and management of breast cancer
(NUI Galway, 2021-07-06)Global statistics have demonstrated that breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among female patients, accounting for 23 percent of total cancer cases and 14 percent of ... -
The design, manufacture and testing of a composite polysialic acid mimetic peptide loaded collagen nerve graft for use in peripheral nerve repair
(NUI Galway, 2016-02-15)Peripheral nerve injuries can be debilitating for patients. The current gold-standard technique for peripheral nerve repair is autograft. This procedure involves harvesting a non-critical nerve from a donor site from the ... -
Development of 3D breast cancer model to study extracellular vesicle crosstalk
(NUI Galway, 2024-01-31)3D model systems are crucial in establishing novel therapeutics and understanding cell interactions in the tumor microenvironment. Extracellular vesicles (EVs) are promising carriers of therapeutic cargo for tumor-targeted ... -
Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery – a pilot study
(Wiley, 2019-11-07)Diabetes mellitus (DM) is associated with an elevated risk of post-operative complications. The impact it has on patients living with DM following hip fracture surgery (HFS) is not completely understood, and may represent ... -
Differentiated thyroid cancer – Evaluation of contemporary management and novel risk assessment
(NUI Galway, 2021-07-08)Introduction Differentiated thyroid cancer (DTC) is a heterogeneous disease with a spectrum of phenotypes ranging from indolent to aggressive variants. The incidence of DTC has increased by 300% over the past 15 years ... -
Effects of remote ischaemic preconditioning on vascular and general surgery patients’ outcomes
(NUI Galway, 2017-09-29)Remote ischaemic preconditioning (RIPC) has been suggested as a non-invasive treatment option in many recent studies. The focus of this thesis is to evaluate the possible effect of this on major health problems in vascular ... -
Evaluation of a markerless motion capture system in a Premier League Football Academy
(NUI Galway, 2021-08-17)Current practice of movement analysis in elite youth football Academies is largely qualitative and confounded by bias. This thesis aimed to investigate a novel Markerless motion capture system that attempts to infer ... -
Exosomal microRNAs in colorectal cancer
(2016)Cancer cells have been shown to release a variety of extracellular membrane vesicles including microvesicles known as exosomes. Exosomes have recently been found to contain microRNAs (miRNAs) however the full range within ... -
Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer
(2016-06-15)Breast cancer is a heterogeneous group of diseases survival from which depends on stage at diagnosis. The development of blood-based biomarkers which may facilitate earlier detection and possibly subtype delineation remains ... -
Expression Profiling of circulating micro-RNAs in Prostate Cancer
(2013-08-06)Mi(cro)RNAs are small non-coding RNAs whose differential expression in tissue has been implicated in the development and progression of many malignancies, including prostate cancer. The discovery of miRNAs in the blood of ... -
Extracellular vesicle encapsulated microRNAs and breast cancer
(NUI Galway, 2023-02-24)Breast cancer is the most prevalent cancer among women worldwide. There is a clear need for earlier detection methods and more personalised treatments. Extracellular vesicle encapsulated microRNA (EV-miR) provide novel ... -
Factors influencing diagnosis and outcome in HER2 receptor positive breast cancer
(NUI Galway, 2019-02-22)Introduction About 30% of breast cancers are HER2 receptor positive, these breast cancers traditionally had a poor prognosis but the introduction of targeted anti-HER2 therapy (Trastuzumab) has resulted in a vast improvement ... -
Genetic determinants of disease characteristics of inflammatory bowel disease and diverticulitis
(2015-05-05)Background: Inflammatory Bowel Disease (IBD) is a complex, multigenic disease in which both the innate and adaptive immune systems play a strong role. Although over 40 microbes including bacteria, viruses and yeasts and ...