Browsing by Subject "Biomedical Engineering"
Now showing items 1-20 of 26
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Analysis and Implementation of Mixed-Mode Cohesive Zone Formulations for Cardiovascular Biomechanics Applications
(2013-02-18)A comprehensive theoretical analysis of potential-based and non-potential-based cohesive zone models (CZMs) under mixed-mode conditions is presented. Using the well established Xu-Needleman (XN) CZM, it is demonstrated ... -
Computational and experimental analysis of the mechanical performance of SLS generated polymer-ceramic bone scaffold materials
(2014-09-30)The load-bearing ability of orthopaedic scaffolds in critical-sized defects is of critical importance. 3D printing methods such as selective laser sintering (SLS) have great potential for the fabrication of patient-specific ... -
A computational investigation of the long-term performance of bioabsorbable magnesium-based implants in orthopaedic fracture applications
(NUI Galway, 2023-06-20)Current orthopaedic fixation devices made from stainless steel and titanium can lead to a range of long-term complications that include bone reabsorption due to stress shielding, implant loosening and/or infection. ... -
Computational modelling framework for predicting the evolution of biodegradable polymers during degradation
(NUI Galway, 2022-11-28)Biodegradable polymers are attractive alternatives for many permanent implants, potentially reducing long term risks. Designing optimal devices for their intended purpose, however, is costly and time consuming, with small ... -
Development of bioabsorbable polymeric textile scaffolds for tissue engineering applications
(NUI Galway, 2023-12-18)Critical-sized bone defects are defined as those that will not heal spontaneously within a patient’s lifetime. Tissue engineering aims to solve such problems by combining highly porous biomaterial scaffold with cells ... -
Development of Simplified NIPAm-based Thermoresponsive Films for Cell Preservation, Expansion and Differentiation
(2013-12-16)Traditional cell recovery methodologies cleave cell-to-cell junctions and thus the recovery of an intact cell sheet for use in tissue engineering is rendered impossible. Additionally, these traditional cell detachment ... -
Experimental and computational investigation into mechanobiology of osteocytes
(2014-10-31)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which comprise over 90% of the cells in mature bone tissue and are known to be highly sensitive to extracellular mechanical cues. The effect ... -
An experimental and computational investigation of the corrosion behaviour and mechanical performance of a bioabsorbable medical grade magnesium alloy
(NUI Galway, 2023-05-29)Magnesium-based medical implants have the potential to overcome several complications that arise with permanent metallic implants. Magnesium-based implants are biodegradable such that they can undergo absorption once ... -
Experimental and computational investigation of the impact of distorted stent expansion on the performance of transcatheter aortic valve replacements
(2014-12-22)Patients with calcific aortic valve stenosis present with calcium deposits on the aortic valve, which can result in non-circular and distorted expansion of self-expanding Transcatheter Aortic Valve Replacements. The effect ... -
An experimental and computational investigation of the mechanics of degradation in polymer bioresorbable scaffolds
(NUI Galway, 2023-10-03)Drug-eluting stents (DES) have established themselves as the gold-standard in treating arterial blockages, with over 1.3 million stent procedures carried out across Europe in coronary vessels alone. However, these permanent ... -
An experimental investigation on the biomechanics of bone fragility in type 2diabetes
(NUI Galway, 2023-10-11)Type 2 diabetic patients experience up to a 3-fold increase in bone fracture risk. Paradoxically, type 2 diabetes is associated with a normal or increased bone mineral density (BMD) when compared to non-diabetic patients. ... -
Glycobiology of commensal bacteria with emphasis on cell surface adhesins and exopolysaccharides
(2014-09-25)The human gastro-intestinal tract (GIT) is an elaborate ecosystem specific to an individual and his physiological stage that involves inter- and intra-relationships between the bacteria composing the microbiota and between ... -
The influence of collagen type I source and cross-linking on cell function and phenotype maintenance
(NUI Galway, 2023-09-13)Collagen is a complex supramolecular structure that occurs in highly diverse morphologies across different tissues, lending them a range of physical and biological functions. Collagens have a long history in both ... -
An investigation into computational modelling strategies to predict the in vitro performance of aortic valve replacements
(NUI Galway, 2023-06-19)The development and design of effective aortic valve replacements (AVRs) presents significant challenges given the structural and hemodynamic performance requirements that must be achieved. Conventional design approaches ... -
An investigation into the role of fibre bridging as a toughening mechanism in engineered composite materials
(NUI Galway, 2022-06-27)Fibre reinforced composites are becoming increasingly popular in engineering design due to their high strength to weight ratio. In one of the failure mechanisms, which can occur during impact, fibres can bridge between ... -
The mechanical environment of the stem cell niche in bone marrow
(2014-06-13)Understanding how bone marrow mesenchymal stem cells (MSCs) contribute to new bone formation and remodelling in vivo is of principal importance for informing the development of effective bone tissue engineering strategies ... -
Mechanobiological origins of osteolysis during bone metastasis
(NUI Galway, 2023-03-28)Metastasis is the final, lethal stage of cancer where cells migrate from a primary tumour site to colonise a secondary organ and is the primary cause of mortality in cancer patients. Breast cancer is the leading cause ... -
Mechanobiological Origins of Osteoporosis
(2013-09-30)The osteocyte is believed to act as the primary sensor of mechanical stimulus in bone, controlling signalling for bone growth and resorption in response to changes in the mechanical demands placed on bones throughout life. ... -
Micromechanical modelling of poly-l-lactide degradation in bioresorbable polymeric stents
(NUI Galway, 2024-03-13)Biodegradable semi-crystalline polymers, such as poly (L-lactic acid) (PLLA), have shown initially promising results as a replacement for permanent implants such as vascular stents, but their detailed mechanical response ... -
Modelling the mechanical and fatigue behaviour of superelastic NiTi: analysing the role of microstructural phase and crystallographic texture
(2015-08-26)Superelastic NiTi self-expanding stents push the boundaries of our current understanding of material behaviour which ultimately influences the design of biomedical devices. In particular, the influence of microstructure ...