Browsing by Subject "Biomedical Engineering"
Now showing items 21-26 of 26
-
A multimodal neuromodulation approach to nervous tissue repair and regeneration
(NUI Galway, 2022-01-06)Regeneration of damaged nervous tissue is one of the remaining frontiers for bioengineers. Nerve tissue injuries have devastating consequences and carry substantial economic and social implications. For example, the annual ... -
A multiscale biomechanical investigation of bone fragility in Type-2 Diabetes using a Zucker Diabetic Fatty (ZDF) rat
(NUI Galway, 2024-04-18)Patients with type-2 diabetes (T2D) face an elevated risk of bone fracture, despite often exhibiting normal or increased bone mineral density (BMD). The prevailing theory suggests that the hyperglycaemic environment ... -
Novel mechanobiological modelling of bone metastasis reveals that substrate stiffness, biochemical bone cell signaling and mechanical stimulation alter metastatic activity
(NUI Galway, 2023-03-01)For more than 70% of breast cancer patients, cancer cells spread from their primary site and metastasize to bone. Although much research has been conducted to understand the pathogenesis of the metastatic bone disease, ... -
Replicating and modulating skin fibrosis in vitro: Multi-compartment collagen devices as dual drug delivery vehicles
(NUI Galway, 2022-01-10)Complex pathologies, such as fibrosis, are often not the result of a singular event, but rather the consequence of multiple disruptions in the normal balance between intricately connected organs, tissues and signalling ... -
Synthesis of model compounds acting as Nitric Oxide (NO)-scavengers and the fabrication of NO-scavenging hydrogels targeting the treatment of triple-negative breast cancer
(NUI Galway, 2023-07-31)Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer, with an early recurrence within two to three years of first diagnosis. Moreover, the heterogeneity of the TNBC tissue creates ... -
Thermal elevations of orthopaedic procedures: A bone cell perspective
(2014-05-27)Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumour ablation, can result in thermal damage leading ...