Browsing by Subject "Animal models"
Now showing items 1-5 of 5
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Development and characterisation of novel gene-environment interaction rat models of Parkinson's disease
(2016-08-04)Despite its discovery almost 60 years ago, levodopa remains the most effective therapy for the treatment of the motor symptoms associated with Parkinson’s disease. However, chronic use of levodopa is associated with serious ... -
The Effect of Pain on Cognitive Function: Preclinical and Clinical Investigations
(2012-10-19)Chronic pain is associated with high social and economic costs due to its disabling physical and psychological effects. Despite some evidence that chronic pain negatively affects cognitive function, little is known about ... -
Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect
(Springer Verlag, 2015-01-15)The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an ... -
Exploration of the opioidergic system in the olfactory bulbectomized rat model of depression
(NUI Galway, 2020-02-27)In recent years, there has been renewed interest in targeting the central opioid system as a novel strategy for the treatment of psychiatric disorders such as depression, due to its involvement in the regulation of mood, ... -
Modelling early life exposure to antidepressants in rats: Developmental, behavioural and neurochemical aspects
(2013-02-11)Depression during pregnancy and the postpartum period has been associated with deleterious consequences such as preterm birth, low birth weight and less optimal scores on neonatal reflexes and behaviour. Pharmacological ...