Browsing by Subject "Wound healing"
Now showing items 1-9 of 9
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Current and upcoming therapies to modulate skin scarring and fibrosis
(Elsevier, 2018-08-30)Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response ... -
Design and development of polymeric transfection vectors for gene delivery in Recessive Dystrophic Epidermolysis Bullosa
(2014-07-23)Recessive Dystrophic Epidermolysis Bullosa (RDEB) is caused by mutations in the collagen VII gene (COL7A1) that lead to an alteration of function or a reduction in the amounts of collagen VII protein (C7). Any of these ... -
Development of a mesenchymal stromal cell / collagen scaffold product for treatment of diabetic wounds
(NUI Galway, 2022-08-23)Foot ulceration is a major complication of diabetes mellitus, which results in significant human suffering and a major burden on healthcare systems. Mesenchymal stromal cells (MSCs) emerged as a promising therapeutic ... -
Fibrin Mediated Proangiogenic and Secretory Control Gene Therapy for Compromised Wound Healing
(2012-07-18)Chronic or compromised healing is a major clinical problem. Particularly, in diabetes where the disease process hinders the capacity to repair the tissue damage, the patients are more susceptible to chronic ulcers, especially ... -
In-situ Formed Bioactive Stem Cell Hydrogel Dressings from PEG-based Multifunctional Copolymers for Wound Healing
(2013-07-23)Wound healing, especially chronic wound healing, has become a major clinical problem all over the world. Among all the treatments for wound healing, wound dressings are the main management approaches for both acute and ... -
Migrastatin analogues inhibit canine mammary cancer cell migration and invasion.
(PlosOne, 2013-10-08)Cancer spread to other organs is the main cause of death of oncological patients. Migration of cancer cells from a primary tumour is the crucial step in the complex process of metastasis, therefore blocking this process ... -
Porcine peritoneum: A multifunctional xenograft for a diverse range of clinical indications
(NUI Galway, 2020-12-18)Decellularised xenografts are an inherent component of regenerative medicine. Their preserved structure, mechanical integrity and biofunctional composition have well established them in reparative medicine for a diverse ... -
Therapeutic applications of endothelial progenitor cells for diabetic ulcer healing
(2016-10-16)Diabetic ulcer healing is a major problem in health care. Impaired circulation has long been associated with diabetes resulting in an increased risk of foot ulceration and making an increase in blood flow an excellent ... -
Wound healing and scar wars
(Elsevier, 2018-06-15)Wound healing and scarring are highly conserved physiological responses to wounding in most tissues in higher organisms, consisting of a sequence of well-characterised stages (coagulation, inflammation, proliferation and ...