Browsing by Author "Dolan, Eimear B."

Now showing items 1-12 of 12

    • A methylcellulose and collagen based temperature responsive hydrogel promotes encapsulated stem cell viability and proliferation in vitro 

      Payne, Christina; Dolan, Eimear B.; O’Sullivan, Janice; Cryan, Sally-Ann; Kelly, Helena M. (Springer Nature, 2016-12-06)
      With the number of stem cell-based therapies emerging on the increase, the need for novel and efficient delivery technologies to enable therapies to remain in damaged tissue and exert their therapeutic benefit for extended ...

    • An actuatable soft reservoir modulates host foreign body response 

      Dolan, Eimear B.; Varela, C. E.; Mendez, K.; Whyte, W.; Levey, R. E.; Robinson, S. T.; Maye, E.; O’Dwyer, J.; Beatty, R.; Rothman, A.; Fan, Y.; Hochstein, J.; Rothenbucher, S. E.; Wylie, R.; Starr, J. R.; Monaghan, M.; Dockery, P.; Duffy, G. P.; Roche, E. T. (American Association for the Advancement of Science, 2019-08-28)
      The performance of indwelling medical devices that depend on an interface with soft tissue is plagued by complex, unpredictable foreign body responses. Such devices—including breast implants, biosensors, and drug delivery ...

    • Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels 

      Dolan, Eimear B.; Kovarova, Lenka; O'Neill, Hugh; Pravda, Martin; Sulakova, Romana; Scigalkova, Ivana; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Cooney, Gerard M .; Bellavia, Gabriella; Straino, Stefania; Cavanagh, Brenton L.; Flanagan, Aiden; Kelly, Helena M.; Kelly, Helena M.; Duffy, Garry P.; Murphy, Bruce P. (SAGE Publications, 2018-10-25)
      Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical ...

    • A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction 

      Dolan, Eimear B.; Hofmann, Björn; de Vaal, M. Hamman; Bellavia, Gabriella; Straino, Stefania; Kovarova, Lenka; Pravda, Martin; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Monahan, David S.; Levey, Ruth E.; O'Neill, Hugh; Hinderer, Svenja; Greensmith, Robert; Monaghan, Michael G.; Schenke-Layland, Katja; Dockery, Peter; Murphy, Bruce P.; Kelly, Helena M.; Wildhirt, Stephen; Duffy, Garry P. (Elsevier, 2019-05-15)
      The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the ...

    • Development of bioabsorbable polymeric textile scaffolds for tissue engineering applications 

      Caronna, Flavia (NUI Galway, 2023-12-18)
      Critical-sized bone defects are defined as those that will not heal spontaneously within a patient’s lifetime. Tissue engineering aims to solve such problems by combining highly porous biomaterial scaffold with cells ...

    • Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform 

      Whyte, William; Goswami, Debkalpa; Wang, Sophie X.; Fan, Yiling; Ward, Niamh A.; Levey, Ruth E.; Beatty, Rachel; Robinson, Scott T.; Sheppard, Declan; O’Connor, Raymond; Monahan, David S.; Trask, Lesley; Mendez, Keegan L.; Varela, Claudia E.; Horvath, Markus A.; Wylie, Robert; O’Dwyer, Joanne; Domingo-Lopez, Daniel A.; Rothman, Arielle S.; Duffy, Garry P.; Dolan, Eimear B.; Roche, Ellen T. (Nature Research, 2022-08-03)
      Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal ...

    • An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure 

      Curley, Clive J.; Dolan, Eimear B.; Otten, Matthias; Hinderer, Svenja; Duffy, Garry P.; Murphy, Bruce P. (Springer Verlag, 2018-12-03)
      As treatments for myocardial infarction (MI) continue to improve, the population of people suffering from heart failure (HF) is rising significantly. Novel treatment strategies aimed at achieving long-term functional ...

    • Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions 

      Gallagher, Laura B.; Dolan, Eimear B.; O'Sullivan, Janice; Levey, Ruth; Cavanagh, Brenton L.; Kovarova, Lenka; Pravda, Martin; Velebny, Vladimir; Farrell, Tom; O'Brien, Fergal J.; Duffy, Garry P. (Elsevier, 2020-03-04)
      The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has been proposed to promote cell adhesion to the matrix, which can influence and control cell behaviour and function. While many studies ...

    • Thermal elevations of orthopaedic procedures: A bone cell perspective 

      Dolan, Eimear B. (2014-05-27)
      Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumour ablation, can result in thermal damage leading ...

    • Thermally induced osteocyte damage initiates a remodelling signaling cascade 

      Dolan, Eimear B.; Haugh, Margaret; Voisin, Muriel C.; Tallon, David; McNamara, Laoise M. (Public Library of Science, 2015-03-18)
      Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumor ablation, can result in thermal damage leading ...

    • Thermally induced osteocyte damage initiates a remodelling signaling cascade 

      Dolan, Eimear B.; Haugh, Matthew G.; Voisin, Muriel C.; Tallon, David; McNamara, Laoise M. (Public Library of Science (PLoS), 2015-03-18)
      Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumor ablation, can result in thermal damage leading ...

    • Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expressionin vivo 

      Dolan, Eimear B.; Tallon, David; Cheung, Wing-Yee; Schaffler, Mitchell B.; Kennedy, Oran D.; McNamara, Laoise M. (The Royal Society, 2016-06-01)
      Bone is often subject to harsh temperatures during orthopaedic procedures resulting in thermally induced bone damage, which may affect the healing response. Postsurgical healing of bone is essential to the success of ...