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Now showing items 6489-6508 of 14646
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Identification of common variants associated with human hippocampal and intracranial volumes
(Springer Nature, 2012-04-15)Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's ... -
Identification of components of the sigma b regulon in listeria monocytogenes that contribute to acid and salt tolerance
(American Society for Microbiology, 2008-09-19)Sigma B (sigma(B)) is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study ... -
Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance
(American Society for Microbiology, 2008-09)Sigma B is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study we ... -
Identification of compounds that may be repurposed for the treatment of triple negative breast cancer
(2012-11-21)Triple negative breast cancers (TNBC), lack the estrogen and progesterone receptors as well as the HER2 receptor. Currently, there is no selective therapy for the treatment of TNBC and current treatment regimens rely on a ... -
The identification of decision constructs in online transactional processes
(2014)From prior research, the authors found that certain design features amongst some online retailers were atypical of ‘good’ design elsewhere. It was apparent the transactional process was being used to present consumers with ... -
Identification of decisive molecular interactions regulating resistance to apoptosis in tumour cells
(14-07-04)TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ... -
Identification of endogenous control genes for normalisation of real-time quantitative pcr data in colorectal cancer
(Springer Nature, 2010-01-01)Background: Gene expression analysis has many applications in cancer diagnosis, prognosis and therapeutic care. Relative quantification is the most widely adopted approach whereby quantification of gene expression is ... -
Identification of genes expressed in the gill tissue of the pacific oyster (crassostrea gigas) using expressed-sequence tags
(Oxford University Press (OUP), 2002-11-01) -
Identification of growth limiting factors in Synechocystis sp. PCC 6803
(2018-02-15)In this study we showed that Synechocystis sp. PCC 6803 can achieve fast division rates using urea, a low-cost nitrogen source that does not require energy for uptake and hydrolysis, and releases CO2 into to the cell during ... -
Identification of host-specific bacteroidales 16s rdna sequences from human sewage and ruminant feces
(Wiley-Blackwell, 2011-09-23) -
Identification of imprinted genes subject to parent-of-origin specific expression in Arabidopsis thaliana seeds
(2011)Background: Epigenetic regulation of gene dosage by genomic imprinting of some autosomal genes facilitates normal reproductive development in both mammals and flowering plants. While many imprinted genes have been identified ... -
Identification of imprinted genes subject to parent-of-origin specific expression in arabidopsis thaliana seeds
(Springer Nature, 2011-01-01)Background: Epigenetic regulation of gene dosage by genomic imprinting of some autosomal genes facilitates normal reproductive development in both mammals and flowering plants. While many imprinted genes have been identified ... -
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
(Springer Nature, 2016-06-21)Background: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. Method: We performed a fine-scale ... -
Identification of IRS4 and TOP2A as novel CDC7 kinase interacting proteins
(2016-02-08)CDC7 is an essential serine/threonine kinase required for the initiation of DNA replication in eukaryotic cells, through phosphorylating the MCM helicase complex. Formation of an active kinase requires the binding to ... -
Identification of novel chicken estrogen receptor- messenger ribonucleic acid isoforms generated by alternative splicing and promoter usage
(The Endocrine Society, 1998-11-01)Using the rapid amplification of complementary DNA ends (RACE) methodology we have identified three new chicken estrogen receptor-ol (cER alpha) messenger RNA (mRNA) variants in addition to the previously described form ... -
Identification of novel cis-regulatory elements of Eya1 in Xenopus laevis using BAC recombineering
(Nature Publishing Group, 2017-11-03)The multifunctional Eya1 protein plays important roles during the development of cranial sensory organs and ganglia, kidneys, hypaxial muscles and several other organs in vertebrates. Eya1 is encoded by a complex locus ... -
Identification of novel cis-regulatory elements of eya1 in xenopus laevis using bac recombineering
(Springer Nature, 2017-11-03)The multifunctional Eya1 protein plays important roles during the development of cranial sensory organs and ganglia, kidneys, hypaxial muscles and several other organs in vertebrates. Eya1 is encoded by a complex locus ... -
Identification of novel drug combinations for haematological malignancies
(2015-01-29)TNF-related apoptosis ligand (TRAIL) is a tumour selective cytokine with potential anti-cancer activity which is currently in clinical trials. Haematological malignancies along with several other cancers have showed varied ... -
Identification of novel factors that promote trinucleotide repeat instability
(2013-09-23)Trinucleotide repeat (TNR) expansions are the genetic cause of several inherited neurological diseases. Factors that affect the propensity of TNRs to expand include the characteristics of the TNR DNA, the chromatin ... -
Identification of novel genetic markers of breast cancer survival
(Oxford University Press (OUP), 2015-04-18)Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with ...