Browsing by Title
Now showing items 4803-4822 of 14647
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Evolutionary Models for the Human Immunodeficiency Virus with Applications to Epitope Prediction and the Natural Selection of Escape Variants
(2012-02-08)In this thesis, evolutionary models are developed for protein coding sequences of the human immunodeficiency virus (HIV). These models are applied to predict the epitopes targeted by the cell-mediated and humoral arms of ... -
Evolutionary origins of brassicaceae specific genes in arabidopsis thaliana
(Springer Nature, 2011-02-18)Background: All sequenced genomes contain a proportion of lineage-specific genes, which exhibit no sequence similarity to any genes outside the lineage. Despite their prevalence, the origins and functions of most lineage ... -
Evolutionary progression in cephalopods using molecular techniques and new approaches to morphology
(NUI Galway, 2021-05)Cephalopods evolved during the Cambrian and were once the dominant lifeforms in the world’s oceans. Several groups of the 800 living cephalopod species have diversified due to their rapid response to drivers of ... -
Evolutionary trade-offs associated with loss of pmrb function in host-adapted pseudomonas aeruginosa
(Springer Nature, 2018-07-06)Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved ... -
Evolving collective behaviours in simulated kilobots
(Association for Computing Machinery, 2018-04-09)The field of Evolutionary Robotics has multiple common tasks and widely used benchmark activities such as navigation, obstacle avoidance, and phototaxis. We present an evolutionary approach to learning behaviours that ... -
The evolving menace of ransomware: A comparative analysis of pre-pandemic and mid-pandemic attacks
(Association for Computing Machinery, 2023-10-20)Drawing upon direct interviews and secondary sources, this article presents a qualitative comparative analysis of 39 ransomware attacks, 26 of which occurred shortly before the outbreak of the COVID-19 pandemic and 13 of ... -
Evolving Racetrack Knowledge in a Racing Game.
(21st National Conference on Artificial Intelligence and Cognitive Science, 2010-07-30)This paper discusses the use of a Genetic Algorithm (GA) to evolve waypoint-based racing lines for computer-controlled cars in an online game. One goal is the reduction of developer effort, in order to automatically produce ... -
Ex vivo generation of bone marrow derived regulatory dendritic cells for promotion of corneal allograft survival.
(2013-09-27)Investigations into cell based therapies for application in organ transplantation has grown significantly. Here, I describe the ex vivo generation of donor bone marrow derived dendritic cells (BMDCs) and examine the ... -
Ex vivo investigation of iron handling in the brain
(2016-11-04)Aberrant iron deposition in the brain is associated with aging and neurodegenerative disorders including multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. It is unclear whether metabolic dyshomeostasis of ... -
Ex Vivo slice culture model of rat spinal cord injury as a platform for testing proposed treatment strategies
(NUI Galway, 2018-04-13)There are several detrimental events that occur in the aftermath of a spinal cord injury (SCI); these include glial scar formation, accumulation of axon growth inhibitors and immune mediators. These events present challenges ... -
Ex-vivo generation of regulatory T-cells expressing transcription factor foxp3 and their application in cornea transplantation
(2011-05-27)This project investigated the therapeutic potential of allo-antigen specific regulatory T-cells in the context of penetrating keratoplasty. Two methods of ex-vivo generation of T regulatory cells have been explored in ... -
Exacerbated LPS/GalN-induced liver injury in the stress-sensitive Wistar Kyoto rat is associated with changes in the endocannabinoid system
(MDPI, 2020-08-23)Acute liver injury (ALI) is a highly destructive and potentially life-threatening condition, exacerbated by physical and psychological stress. The endocannabinoid system plays a key role in modulating stress and hepatic ... -
An examination of diathesis and its didactic practices in Latin grammars from late antiquity to the early Middle Ages
(2016-12-21)This thesis traces the origin and development of the category of diathesis (or voice) in Antiquity. According to modern linguistic theory, diathesis is a verbal category which describes the relationship between the action ... -
Examination of Flood Estimation Techniques in the Irish Context
(2010-07-07)This thesis deals with the determination of the most suitable methods of finding the food magnitude-return period relationship for Irish flood data using the annual maximum statistical model. Data from approximately 200 ... -
An examination of gender differences in the impact of individual and organisational factors on work hours, work-life conflict and psychological strain in academics
(Routledge / Taylor & Francis, 2015-04-21)The current study used multi-group structural equation modelling (SEM) to test a fully and partially mediated Extended Rational Model of Work-Life Conflict and examine the impact of job involvement, workaholism, work ... -
An examination of glass beads from early medieval Ireland
(2013-08-18)This is the first dedicated and comprehensive study of glass beads from Early Medieval Ireland, presenting the first national classification, typology, dating and consideration of the social context and symbology of glass ... -
Examination of homogeneity of selected Irish pooling groups
(2010)In regional flood frequency estimation, a homogeneous pooling group of sites leads to a reduction in the error of quantile estimators which is the main aim of a regional flood frequency analysis. Examination of the homogeneity ... -
Examination of homogeneity of selected irish pooling groups
(Copernicus GmbH, 2011-03-09)Flood frequency analysis is a necessary and important part of flood risk assessment and management studies. Regional flood frequency methods, in which flood data from groups of catchments are pooled together in order to ... -
An examination of maximum legal application rates of dairy processing and associated STRUBIAS fertilising products in agriculture
(Elsevier, 2021-10-09)The dairy industry produces vast quantities of dairy processing sludge (DPS), which can be processed further to develop second generation products such as struvite, biochars and ashes (collectively known as STRUBIAS). These ... -
An examination of migrant preferences for health and healthcare
(NUI Galway, 2022-04-20)Understanding the needs and preferences of migrant groups presents challenges to their host countries, including that of the host country's healthcare system. Migrants are a distinct subpopulation of the host country's ...