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Now showing items 3480-3499 of 14646
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Development of anisotropic polymeric substrates for tendon tissue engineering
(2015-09-11)Tendon injuries and degenerative conditions constitute an unmet clinical need with pharmacological strategies and tissue grafts failing to recapitulate native tendon function. Advancements in bioengineering have enabled ... -
Development of bioabsorbable polymeric textile scaffolds for tissue engineering applications
(NUI Galway, 2023-12-18)Critical-sized bone defects are defined as those that will not heal spontaneously within a patient’s lifetime. Tissue engineering aims to solve such problems by combining highly porous biomaterial scaffold with cells ... -
Development of computationally efficient nested hydrodynamic models
(2014-04-25)Hydrodynamic numerical modelling of coastal zones typically requires a high level of horizontal spatial resolution to improve the realism of its solution, particularly in areas of complex bathymetry. These high resolution ... -
Development of correlated and computational methods for predicting premixed turbulent flame speed
(NUI Galway, 2018-10-02)Turbulent flame speed is an important property within turbulent flames and an invaluable parameter for gas turbine combustor design. A major issue however is the difficulty in accurately predicting turbulent flame speed ... -
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
(NUI Galway, 2019-02-15)The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ... -
Development of efficient data assimilation methods for solute transport problems
(NUI Galway, 2018-09-18)The solution of marine contaminant transport problems is a significant research topic in civil engineering. Typically, the problem is represented as a partial differential equation described by the non-stationary, ... -
The development of entrustable professional activities for the Irish intern year
(NUI Galway, 2018-09)There have been significant reforms in intern training in Ireland over the last decade to bring about improvements for the benefit of trainees, health services and ultimately the public. Activities undertaken by the Medical ... -
The Development of Farmed Cod in Ireland
(2012-05-25)This study is interlinked with the work programme of the EIROCD project. Utilising historical data and empirical experimental approaches, various aspects of development, growth and phenotypic plasticity of North Atlantic ... -
Development of filtration technologies for effective, cost-efficient and robust water treatment
(2016-08-12)The provision of high quality, potable water in a sustainable and effective manner is a key challenge for water engineers, scientists, and policy makers. Urbanisation and industrial development, along with population ... -
Development of glucose-oxidising enzyme electrodes for application in glucose|oxygen powered enzymatic fuel cells
(2016-02)The objective of this thesis is to investigate different strategies for the optimisation of biocatalytic anodes with a view to developing a semi- or fully implantable, miniature, membrane-less enzymatic fuel cell via ... -
Development of high-resolution multi-scale modelling system for simulation of coastal-fluvial urban flooding
(Copernicus Publications, 2017-02-16)Urban developments in coastal zones are often exposed to natural hazards such as flooding. In this research, a state-of-the-art, multi-scale nested flood (MSN_Flood) model is applied to simulate complex coastal-fluvial ... -
Development of life assessment procedures for power plant headers operated under flexible loading scenarios
(Elsevier ScienceDirect, 2013-12-22)A finite element methodology for thermo-mechanical fatigue analysis of a subcritical power plant outlet header under realistic loading conditions is presented. The methodology consists of (i) a transient heat transfer ... -
Development of long-term daily maximum and minimum air temperature series and assessment of past extreme air temperature events in Ireland
(NUI Galway, 2021-05-06)Despite the rich heritage of meteorological observations registered in Ireland, prior to this PhD research, numerous historical daily air temperature records remained only in paper data sources across multiple archives, ... -
Development of Mcl-1 inhibitors for cancer therapy
(Elsevier, 2020-11-24)The myeloid leukemia cell differentiation protein (Mcl-1) is an anti-apoptotic protein of the B-cell lymphoma 2 (Bcl-2) family, which regulates cellular apoptosis. Mcl-1 expression plays a key role in survival of cancer ... -
Development of Mediated Enzymatic Fuel Cells for Operation in Blood
(2013-07)The process of enzymatic catalysis of glucose oxidation releases electrons which, when harnessed to flow through a circuit, may be utilised to power devices. This principle has driven research towards the goal of providing ... -
Development of mid-infrared spectroscopic methods for the determination of soil chemical quality in tillage fields
(NUI Galway, 2021-04-30)Healthy soils are the foundation for a prosperous future by providing nutrition, clean water, and the basis for all biodiversity on land. But soil health is threatened by soil degradation and climate change. To improve ... -
The Development of Monitoring Tools for ISPCC Services
(2008-11)The ISPCC Citizen Child Strategy (ISPCC, 2005) includes a proposal to evaluate the effect of its work. In order to undertake such an evaluation, a system of performance and outcome measurement that was valid and reliable ... -
Development of multiplex real-time PCR assays for the detection and identification of ESKAPE pathogens and their closely related species complexes: Toward reducing the occurrence of healthcare-associated infection using enhanced surveillance of clinical and environmental samples
(NUI Galway, 2023-08-18)Microorganisms have the ability cause a wide range of infections in humans - from superficial skin infections to invasive pneumonia and sepsis. Advancements in medical technology, as well as an expanding global population, ... -
Development of multipurpose skeletal core combustion chemical kinetic mechanisms
(American Chemical Society, 2021-03-25)Core combustion kinetic mechanisms for small C0¿C4 fuel molecules are not only of the utmost importance in understanding their individual combustion properties but are also the foundation for the development of kinetic ...