Search
Now showing items 1-10 of 18
Overexpression of wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development
(Wiley-Blackwell, 2014-10-10)
Increased Wnt5a expression has been observed in psoriatic plaques. However, whether Wnt5a overexpression directly causes psoriasis is unknown. In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression ...
Facets of diazotrophy in the oxygen minimum zone waters off peru
(Springer Nature, 2014-05-09)
Nitrogen fixation, the biological reduction of dinitrogen gas (N-2) to ammonium (NH4+), is quantitatively the most important external source of new nitrogen (N) to the open ocean. Classically, the ecological niche of oceanic ...
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
(Springer Nature, 2014-11-15)
Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ...
Development of a cucumis sativus tilling platform for forward and reverse genetics
(Public Library of Science (PLoS), 2014-05-16)
Background: Cucumber (Cucumis sativus) belongs to the Cucurbitaceae family that includes more than 800 species. The cucumber genome has been recently sequenced and annotated. Transcriptomics and genome sequencing of many ...
Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin-resistantstaphylococcus aureusstrain lac
(Oxford University Press (OUP), 2014-04-01)
Community-associated methicillin-resistant Staphylococcus aureus of the USA300 lineage is emerging as an important cause of medical device-related infection. However, few factors required for biofilm accumulation by USA300 ...
Identification and validation of oncologic mirna biomarkers for luminal a-like breast cancer
(Public Library of Science (PLoS), 2014-01-31)
Introduction: Breast cancer is a common disease with distinct tumor subtypes phenotypically characterized by ER and HER2/neu receptor status. MiRNAs play regulatory roles in tumor initiation and progression, and altered ...
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
(Springer Nature, 2014-07-30)
Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few blood cells that truly age(1,2). Paradoxically, although HSCs numerically expand with age, their functional activity declines over ...
A collagen-based scaffold delivering exogenous microrna-29b to modulate extracellular matrix remodeling
(Elsevier BV, 2014-04-01)
Directing appropriate extracellular matrix remodeling is a key aim of regenerative medicine strategies. Thus, antifibrotic interfering RNA (RNAi) therapy with exogenous microRNA (miR)-29B was proposed as a method to modulate ...
Divergent evolution of the activity and regulation of the glutamate decarboxylase systems in listeria monocytogenes egd-e and 10403s: roles in virulence and acid tolerance
(Public Library of Science (PLoS), 2014-11-11)
The glutamate decarboxylase (GAD) system has been shown to be important for the survival of Listeria monocytogenes in low pH environments. The bacterium can use this faculty to maintain pH homeostasis under acidic conditions. ...
Co-acting gene networks predict trail responsiveness of tumour cells with high accuracy
(Springer Nature, 2014-01-01)
Background: Identification of differentially expressed genes from transcriptomic studies is one of the most common mechanisms to identify tumor biomarkers. This approach however is not well suited to identify interaction ...