Now showing items 1-10 of 11
New roles for old enzymes: killer caspases as the engine of cell behavior changes
(Frontiers Media SA, 2014-04-16)
It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal ...
Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under er stress conditions
(Informa UK Limited, 2014-11-02)
Endoplasmic reticulum (ER) stress-induced cell death is normally associated with activation of the mitochondrial apoptotic pathway, which is characterized by CYCS (cytochrome c, somatic) release, apoptosome formation, and ...
Dr4 specific trail variants are more efficacious than wild-type trail in pancreatic cancer
(Informa UK Limited, 2014-11-20)
Current treatment modalities for pancreatic carcinoma afford only modest survival benefits. TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising new treatment option. However, since ...
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
(Springer Nature, 2014-05-01)
Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ...
A collagen-based scaffold delivering exogenous microrna-29b to modulate extracellular matrix remodeling
(Elsevier BV, 2014-04-01)
Directing appropriate extracellular matrix remodeling is a key aim of regenerative medicine strategies. Thus, antifibrotic interfering RNA (RNAi) therapy with exogenous microRNA (miR)-29B was proposed as a method to modulate ...
Mirna signature of unfolded protein response in h9c2 rat cardiomyoblasts
(Springer Nature, 2014-01-01)
Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ...
Regulation of apoptosis by heat shock proteins