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    New roles for old enzymes: killer caspases as the engine of cell behavior changes

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    Date
    2014-04-16
    Author
    Connolly, Patrick F.
    Jäger, Richard
    Fearnhead, Howard O.
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    Cited 52 times in Scopus (view citations)
    
    Recommended Citation
    Connolly, Patrick F. Jäger, Richard; Fearnhead, Howard O. (2014). New roles for old enzymes: killer caspases as the engine of cell behavior changes. Frontiers in Physiology 5 ,
    Published Version
    https://www.frontiersin.org/articles/10.3389/fphys.2014.00149/pdf
    Abstract
    It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.
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    http://hdl.handle.net/10379/10881
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