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Hereditary deficiency of the seventh component of complement and recurrent meningococcal infection: investigations of an irish family using a novel haemolytic screening assay for complement activity and c7 m/n allotyping
(Cambridge University Press (CUP), 1994-10-01)
Terminal complement component deficiency predisposes to meningococcal infection and is inherited in an autosomal co-dominant manner. An Irish family is described, in which 2 of 3 brothers had recurrent meningococcal ...
Evaluation of the diagnostic utility of spinal magnetic resonance imaging in axial spondylarthritis
(Wiley-Blackwell, 2009-05-01)
Objective. Magnetic resonance imaging (MRI) is increasingly used for the diagnosis of axial spondylarthritis (SpA), but it is unknown whether characteristic lesions are actually specific for SpA. This study was undertaken ...
Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled chart-1 clinical trial
(Oxford University Press (OUP), 2016-12-23)
Aims Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed ...
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the lung safe prospective cohort study
(Elsevier BV, 2017-08-01)
Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of ...
Genetic diversity of the fish pathogen aeromonas salmonicida demonstrated by random amplified polymorphic dna and pulsed-field gel electrophoresis analyses
(Inter-Research Science Center, 2000-01-01)
The current taxonomy of Aeromonas salmonicida includes 4 subspecies. A. salmonicida subsp. salmonicida is associated with salmonid furunculosis, and A. salmonicida subsp, achromogenes, A. salmonicida subsp. masoucida, and ...
Simple method for comparing reliability of two serum tumour markers in breast carcinoma.
(BMJ, 1994-02-01)
Aims-To compare the two breast tumour markers, CA15-3 and mucinous-like carcinoma associated antigen (MCA), using Receiver Operating Characteristic (ROC) curve analysis.
Methods-One hundred and ninety six patients ...
Biological insights from 108 schizophrenia-associated genetic loci
(Springer Nature, 2014-07-22)
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a ...
Molecular profiling: a case of zbtb16-rara acute promyelocytic leukemia
(Hindawi Limited, 2017-01-01)
Several variant RARA translocations have been reported in acute promyelocytic leukemia (APL) of which the t(11;17)(q23;q21), which results in a ZBTB16-RARA fusion, is the most widely identified and is largely resistant to ...
The role of transferrin saturation as a screening test for hereditary haemochromatosis in an irish population seeking medical care
(SAGE Publications, 2003-03-01)
Background Genetic studies have indicated a high prevalence of mutations for hereditary haemochromatosis (HH) in Irish populations. Given the high cost of genetic screening and the ethical implications thereof, we assessed ...