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Cross-sectional analysis of the prevalence and predictors of statin utilisation in ireland with a focus on primary prevention of cardiovascular disease
(BMJ, 2018-02-01)
Objective To describe the prevalence of statin utilisation by people aged over 50 years in Ireland and the factors associated with the likelihood of using a statin, focusing particularly on those using statins for primary ...
Genetic loci controlling carotenoid biosynthesis in diverse tropical maize lines
(Genetics Society of America, 2018-01-29)
The discovery and use of genetic markers associated with carotenoid levels can help to exploit the genetic potential of maize for provitamin A accumulation more effectively. Provitamin A carotenoids are classes of carotenoids ...
Dual ire1 rnase functions dictate glioblastoma development
(EMBO, 2018-01-08)
Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...
Evolutionary trade-offs associated with loss of pmrb function in host-adapted pseudomonas aeruginosa
(Springer Nature, 2018-07-06)
Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved ...
A comparative examination of healthcare use related to hearing impairment in europe
(SAGE Publications, 2018-01-01)
Introduction: The economic burden of hearing impairment is an area of increased interest. In this paper we examine the relationship between hearing impairment and service use in 14 European countries.
Methods: Based on the ...
Tgf-β1/cd105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels
(Public Library of Science (PLoS), 2018-03-22)
Cell-based strategies for the treatment of ischemic diseases are at the forefront of tissue engineering and regenerative medicine. Cell therapies purportedly can play a key role in the neovascularization of ischemic tissue; ...
Maristem—stem cells of marine/aquatic invertebrates: from basic research to innovative applications
(MDPI AG, 2018-02-15)
The "stem cells" discipline represents one of the most dynamic areas in biomedicine. While adult marine/aquatic invertebrate stem cell (MISC) biology is of prime research and medical interest, studies on ...
Towards a generalized approach for deep neural network based event processing for the internet of multimedia things
(Institute of Electrical and Electronics Engineers (IEEE), 2018-01-01)
Event processing systems serve as a middleware between the Internet of Things (IoT) and the application layer by allowing users to subscribe to events of interest. Due to the increase of multimedia IoT devices (i.e. traffic ...
Synthesis of n-[(dialkylamino)methyl)]acrylamides and n-[(dialkylamino)methyl]methacrylamides from schiff base salts: useful building blocks for smart polymers
(Royal Society of Chemistry (RSC), 2018-01-01)
The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these monomeric ...