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Now showing items 11-18 of 18
The sialyltransferase st3gal6 influences homing and survival in multiple myeloma
(American Society of Hematology, 2014-07-24)
Glycosylation is a stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process, especially increased sialylation, have been associated with malignant transformation ...
The expression and roles of nde1 and ndel1 in the adult mammalian central nervous system
(Elsevier BV, 2014-06-01)
Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain
(Royal Society of Chemistry (RSC), 2014-01-01)
The purpose of this study was to develop a platform transfection technology, for applications in the brain, which could transfect astrocytes without requiring cell specific functionalization and without the common cause ...
Selective repression of the oncogene cyclin d1 by the tumor suppressor mir-206 in cancers
(Springer Nature, 2014-08-11)
MicroRNAs (miRNAs) are deregulated in cancer and have been shown to exhibit both oncogenic and tumor suppressive functions. Although the functional effects of several miRNAs have been elucidated, those of many remain to ...
Impact of tumour epithelial subtype on circulating micrornas in breast cancer patients
(Public Library of Science (PLoS), 2014-03-13)
While a range of miRNAs have been shown to be dysregulated in the circulation of patients with breast cancer, little is known about the relationship between circulating levels and tumour characteristics. The aim of this ...
Tumor microenvironment-based feed-forward regulation of nos2 in breast cancer progression
(Proceedings of the National Academy of Sciences, 2014-04-14)
Inflammation is widely recognized as an inducer of cancer progression. The inflammation-associated enzyme, inducible nitric oxide synthase (NOS2), has emerged as a candidate oncogene in estrogen receptor (ER)-negative ...
In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (flt3) ligand in hematopoietic development
(Ferrata Storti Foundation (Haematologica), 2014-01-24)
Cytokines are essential regulators of hematopoiesis, acting in an instructive or permissive way. Fms-like tyrosine kinase 3 ligand (FLT3L) is an important cytokine for the development of several hematopoietic populations. ...
A role for pparα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats
(Wiley-Blackwell, 2014-03-01)
Background and PurposeThe nuclear hormone receptor, PPAR, and its endogenous ligands, are involved in pain modulation. PPAR is expressed in the medial prefrontal cortex (mPFC), a key brain region involved in both the ...