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Differential activation of jnk1 isoforms by trail receptors modulate apoptosis of colon cancer cell lines
(Springer Nature, 2009-04-07)
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5). TRAIL can also activate c-Jun N-terminal kinase (JNK) through the adaptor ...
The trail-receptor-1: trail-receptor-3 and -4 ratio is a predictor for trail sensitivity of cancer cells
(Spandidos Publications, 2009-04-06)
The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in many cancer cells. However, a significant proportion of tumours are TRAIL-resistant erecting a major hurdle for a ...
The apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
(Wiley-Blackwell, 2009-06-04)
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed ...
Stem cells are resistant to trail receptor-mediated apoptosis
(Wiley-Blackwell, 2009-11-01)
New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti-neoplastic protein is tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) because ...
Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome
(Wiley-Blackwell, 2009-02-01)
Objective. Tumor necrosis factor receptor (TNFR) -associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory condition caused by mutations in the TNFRSFIA gene. Unlike other autoinflammatory diseases ...
Histone deacetylase inhibitors cooperate with ifn-γ to restore caspase-8 expression and overcome trail resistance in cancers with silencing of caspase-8
(Springer Nature, 2009-07-13)
Evasion of apoptosis can be caused by epigenetic silencing of caspase-8, a key component of the extrinsic apoptosis pathway. Loss of caspase-8 correlates with poor prognosis in medulloblastoma, which highlights the relevance ...
The mitochondrial death pathway: a promising therapeutic target in diseases
(Wiley-Blackwell, 2009-07-01)
The mitochondrial pathway to apoptosis is a major pathway of physiological cell death in vertebrates. The mitochondrial cell death pathway commences when apoptogenic molecules present between the outer and inner mitochondrial ...