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The synthesis of 1,2,7,11b-tetrahydroisoxazolo[2,3-d][1,4]benzodiazepin-6(5h)-ones and 1,3,3a,9b-tetrahydroisoxazolo[4,3-c]quinolin-4(5h)-ones
(Elsevier BV, 1995-10-01)
The reaction of various ethyl 3-[[2-(1-hydroxyiminoalkyl)phenyl]carbamoyl]acrylates (2) with electron deficient olefins proceeds via a sequential dipole formation, dipolar cycloaddition sequence to furnish the tetrahydro ...
The influence of oxime stereochemistry in the generation of nitrones from ω-alkenyloximes by cyclization or 1,2-prototropy
(Royal Society of Chemistry (RSC), 1998-01-01)
Thermally induced cyclization of the anti-alkenyl oximes E-7a,b and E-17a,b affords cyclic alpha-alkoxycarbonylnitrones 8 and the 6,7-bicyclic nitrones 18, respectively, The syn-oximes Z-7b and Z-17b react via an alternate ...
Site selectivity in the addition of ketoximes to activated allenes and alkynes; n- versus o-alkylation
(Royal Society of Chemistry (RSC), 1999-01-01)
Reaction of ketoximes with methyl propiolate afforded geometrical isomers of the methyl 3-(hydroxyimino)propanoates 4 and of the O-vinyl oximes 5 as well as the 2-isoxazoline 6. With dimethyl penta-2,3-diendioate 8c reaction ...
Steric control of reactivity: formation of oximes, benzodiazepinone n-oxides and isoxazoloquinolinones
(Royal Society of Chemistry (RSC), 1998-01-01)
Reaction of the alkenyl carbonyl compounds 1 with hydroxylamine can lead to the formation of the oximes 2, the benzodiazepinone N-oxides 3 or the isoxazoloquinolinones 5. The product(s) of reaction are shown to depend on ...
Preparation of imidazo[1,2-c]pyrimidinones from a chloropyrimidine and an electron poor ω-allylic amine
(Royal Society of Chemistry (RSC), 1998-01-01)
Synthesis of the title ring system by a sequential intermolecular nucleophilic displacement and intramolecular 'conjugate' addition has been achieved both as a one pot and as a stepwise procedure; an X-ray structure ...
Nitrogen containing heterocycles from aldoximes; a one-pot route to isoxazolobenzodiazepinones, n-substituted and n-unsubstituted isoxazoloquinolinones
(Royal Society of Chemistry (RSC), 1998-01-01)
The aldoximes 1 in the presence of electron poor olefins react to form either the 5,6,7-tricyclic isoxazolobenzodiazepinone 3 or the 5,6,6-tricyclic isoxazoloquinolinone 5 ring skeleton, In each case the ring system formed ...