dc.contributor.author | Ryan, K. A. | |
dc.contributor.author | van Doorn, L.-J. | |
dc.contributor.author | Moran, A. P. | |
dc.contributor.author | Glennon, M. | |
dc.contributor.author | Smith, T. | |
dc.contributor.author | Maher, M. | |
dc.date.accessioned | 2018-08-24T08:26:19Z | |
dc.date.available | 2018-08-24T08:26:19Z | |
dc.date.issued | 2001-05-01 | |
dc.identifier.citation | Ryan, K. A. van Doorn, L.-J.; Moran, A. P.; Glennon, M.; Smith, T.; Maher, M. (2001). Evaluation of clarithromycin resistance and caga and vaca genotyping of helicobacter pylori strains from the west of ireland using line probe assays. Journal of Clinical Microbiology 39 (5), 1978-1980 | |
dc.identifier.issn | 0095-1137 | |
dc.identifier.uri | http://hdl.handle.net/10379/9833 | |
dc.description.abstract | The prevalence of clarithromycin resistance-associated mutations, the cytotoxin-associated gene (cagA), and the various vacuolating cytotoxin (vacA) genotypes was determined in 50 gastric biopsy specimens from Helicobacter pylori-infected patients, using line probe assays, The clarithromycin resistance-associated mutation A2143G was detected in H. pylori strains from 26% of the specimens, which suggested that the high I ate of H, pylori treatment failure in Ireland may be partly attributable to the presence of these mutations,;UI strains examined carried the vacA s1 genotype. and 76% were cagA positive, Of these 50 specimens, 13 (26%) carried H. pylori strains with vacA midregion genotype mi, 29 (58%) carried strains that were m2, 1 (2%) was infected by a strain that was positive for both mi and m2, and 7 (14%) carried strains that could not be typed. | |
dc.publisher | American Society for Microbiology | |
dc.relation.ispartof | Journal of Clinical Microbiology | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | 23s ribosomal-rna | |
dc.subject | reverse hybridization | |
dc.subject | macrolide resistance | |
dc.subject | gene | |
dc.subject | pcr | |
dc.subject | mutations | |
dc.title | Evaluation of clarithromycin resistance and caga and vaca genotyping of helicobacter pylori strains from the west of ireland using line probe assays | |
dc.type | Article | |
dc.identifier.doi | 10.1128/jcm.39.5.1978-1980.2001 | |
dc.local.publishedsource | http://jcm.asm.org/content/39/5/1978.full.pdf | |
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