Evaluation of clarithromycin resistance and caga and vaca genotyping of helicobacter pylori strains from the west of ireland using line probe assays
Ryan, K. A.
van Doorn, L.-J.
Moran, A. P.
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Ryan, K. A. van Doorn, L.-J.; Moran, A. P.; Glennon, M.; Smith, T.; Maher, M. (2001). Evaluation of clarithromycin resistance and caga and vaca genotyping of helicobacter pylori strains from the west of ireland using line probe assays. Journal of Clinical Microbiology 39 (5), 1978-1980
The prevalence of clarithromycin resistance-associated mutations, the cytotoxin-associated gene (cagA), and the various vacuolating cytotoxin (vacA) genotypes was determined in 50 gastric biopsy specimens from Helicobacter pylori-infected patients, using line probe assays, The clarithromycin resistance-associated mutation A2143G was detected in H. pylori strains from 26% of the specimens, which suggested that the high I ate of H, pylori treatment failure in Ireland may be partly attributable to the presence of these mutations,;UI strains examined carried the vacA s1 genotype. and 76% were cagA positive, Of these 50 specimens, 13 (26%) carried H. pylori strains with vacA midregion genotype mi, 29 (58%) carried strains that were m2, 1 (2%) was infected by a strain that was positive for both mi and m2, and 7 (14%) carried strains that could not be typed.