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Molecular and electrophysiological changes in the prefrontal cortex-amygdala-dorsal periaqueductal grey pathway during persistent pain state and fear-conditioned analgesia
(Elsevier, 2011-10)
Fear-conditioned analgesia (FCA) is the reduction in pain responding which is expressed upon re-exposure to a context previously paired with an aversive stimulus. Projections along the prefrontal cortex (PFC)¿amygdala¿dorsal ...
Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions
(2010)
Altered pain responding in depression is a widely recognized but poorly understood phenomenon The present study investigated nociceptive responding to acute (thermal and mechanical) and persistent (inflammatory) noxious ...
Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain
(2012)
Chronic pain is associated with cognitive deficits. Considerable overlap in brain regions involved in pain and aversion suggests that aversive learning and memory may be affected during chronic pain. Passive-avoidance ...
The endocannabinoid system and emotional processing: pathophysiology and therapeutic potential.
(SAGE, 2012-01)
Although the pharmacological and medicinal properties of the plant Cannabis sativa have long been known and appreciated, the discovery of the endocannabinoid system began with the isolation of [delta]9-tetrahydrocannabinol ...
Behavioural, neurochemical and neuroendocrine effects of the endogenous beta-carboline harmane in fear-conditioned rats
(2012)
The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the ...
Brain CB2 receptors: Implication for Neuropsychiatric disorders
(2010)
Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression ...
Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat
(2007)
The olfactory bulbectomized (OB) rat is a well characterized animal model that
exhibits a number of behavioural and neurochemical changes that have relevance to
clinical depression. Hyperactivity in the open field is the ...
Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain
(Elsevier, 2015-01-30)
Acute postoperative pain remains a significant health care issue. Development of anatomically relevant animal models of postoperative pain, with improved predictive validity, would advance understanding of postoperative ...
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor
(Elsevier, 2011-09)
The endocannabinoid system is an important regulator of the nervous, neuroendocrine, and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, ...
Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala
(Elsevier, 2011-04)
Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear, and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA ...