Now showing items 1-6 of 6

    • Acute ischemic stroke secondary to cardiac embolus of a ‘foreign body’ material after a redo sternotomy for mitral valve replacement: A case report 

      Fitzgerald, Seán; Rizvi, Asim; Dai, Daying; Williamson, Eric E.; Lanzino, Giuseppe; Doyle, Karen M.; Kallmes, David F.; Brinjikji, Waleed (SAGE Publications, 2018-11-14)
      Cardiac surgery has been shown to be associated with increased risk of acute ischemic stroke. This report presents a case of a successful mechanical embolectomy procedure to treat a patient for an acute ischemic stroke, ...
    • Fatty acid binding protein expression in clots retrieved by mechanical thrombectomy from patients with acute ischaemic stroke 

      Mereuta, Oana Madalina; Fitzgerald, Seán; Douglas, Andrew; Rossi, Rosanna; Silva Santos, Andreia M.; Pandit, Abhay; Thornton, John; O'Hare, Alan; Power, Sarah; Brennan, Paul; Rentzos, Alexandros; Tatlisumak, Turgut; Gunnarsson, Thorsteinn; Davidson, Maria; Brederlau, Anke; Allardt, Arne; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Sage Publications, 2019-05-22)
      Introduction: Lipid accumulation and inflammation are considered hallmarks of the unstable atherosclerotic plaque. In particular, adipocyte fatty acid binding protein (FABP4) expression within the plaque is associated ...
    • Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots 

      Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Murphree Jr, Dennis H.; Pandit, Abhay; Douglas, Andrew; Rizvi, Asim; Kadirvel, Ramanathan; Gilvarry, Michael; McCarthy, Ray; Stritt, Manuel; Gounis, Matthew J.; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Public Library of Science, 2019-12-05)
      Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical ...
    • Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT 

      Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Douglas, Andrew; Kadirvel, Ramanathan; Gounis, Matthew J.; Chueh, Juyu; Puri, Ajit S.; Layton, Kennith F.; Thacker, Ike C.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Almekhlafi, Mohammed A.; Demchuk, Andrew M.; Nogueira, Raul G.; Pereira, Vitor M.; Kvamme, Peter; Kayan, Yasha; Delgado Almandoz, Josser E.; Yoo, Albert J.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (BMJ Publishing Group, 2019-04-05)
      Background Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize ...
    • Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes 

      Douglas, Andrew; Fitzgerald, Seán; Mereuta, Oana Madalina; Rossi, Rosanna; O'Leary, Sean; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Holmegaard, Lukas; Abrahamsson, Margareta; Jerndal, Mikael; Dehlfors, Niclas; Brennan, Paul; Power, Sarah; O'Hare, Alan; Griffin, Emma; Kallmes, David F.; Brinjikji, Waleed; Szikora, István; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (BMJ Publishing Group, 2019-11-04)
      Background and aims Platelets and von Willebrand factor (vWF) are key factors in thrombosis and thus are likely key components of acute ischemic stroke (AIS) emboli. We aimed to characterize platelet and vWF levels in AIS ...
    • Platelet-rich emboli in cerebral large vessel occlusion are associated with a large artery atherosclerosis source 

      Fitzgerald, Seán; Dai, Daying; Wang, Shunli; Douglas, Andrew; Kadirvel, Ramanathan; Layton, Kennith F.; Thacker, Ike C.; Gounis, Matthew J.; Chueh, Ju-Yu; Puri, Ajit S.; Almekhlafi, Mohammed; Demchuk, Andrew M.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Yoo, Albert J.; Kvamme, Peter; Pereira, Vitor M.; Kayan, Yasha; Delgado Almandoz, Josser E.; Nogueira, Raul G.; Rabinstein, Alejandro A.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (American Heart Association, 2019-05-29)
      Background and Purpose— Nearly 30% of large vessel occlusion acute ischemic stroke clots are from an unknown source. We assessed histological clot composition in a series of patients with large vessel occlusion and ...