Browsing School of Medicine by Author "Fitzgerald, Seán"

Now showing items 1-20 of 23

    • Acute ischemic stroke secondary to cardiac embolus of a ‘foreign body’ material after a redo sternotomy for mitral valve replacement: A case report 

      Fitzgerald, Seán; Rizvi, Asim; Dai, Daying; Williamson, Eric E.; Lanzino, Giuseppe; Doyle, Karen M.; Kallmes, David F.; Brinjikji, Waleed (SAGE Publications, 2018-11-14)
      Cardiac surgery has been shown to be associated with increased risk of acute ischemic stroke. This report presents a case of a successful mechanical embolectomy procedure to treat a patient for an acute ischemic stroke, ...

    • Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization 

      Rossi, Rosanna; Fitzgerald, Seán; Molina Gil, Sara; Mereuta, Oana; Douglas, Andrew; Pandit, Abhay; Brennan, Paul; Power, Sarah; Alderson, Jack; O'Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Psychogios, Klearchos; Magoufis, George; Tsivgoulis, Georgios; Szikora, Istvan; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen (SAGE Publications, 2021-07-07)
      Introduction We assessed the correlation between thrombus size before and after mechanical thrombectomy, measured as length by Computed Tomography Angiography/Non-Contrast Computed Tomography (CTA/NCCT) and Extracted Clot ...

    • Dielectric profile of blood clots to inform ischemic stroke treatments 

      Santorelli, Adam; Fitzgerald, Seán; Douglas, Andrew; Doyle, Karen M.; O’Halloran, Martin (IEEE, 2020-07-20)
      Platelet and fibrin-rich blood clots can respond differently to red blood cell rich clots during ischemic stroke treatment, which includes thrombolysis and mechanical thrombectomy. Currently, there is no accurate way ...

    • Does bridging therapy in mechanical thrombectomy increase recanalization rates in ischemic stroke patients affected by acute large vessel occlusion? 

      Silva Santos, Andreia M.; Rossi, Rosanna; Pandit, Abhay; Fitzgerald, Seán; Mereuta, Oana Madalina; Douglas, Andrew; Thornton, John; Brennan, Paul; Power, Sarah; O’Hare, Alan; Rentzos, Alexandros; Ceder, Erik; Tatlisumak, Turgut; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Duffy, Sharon; Gilvarry, Michael; McCarthy, Ray; Doyle, Karen M. (SAGE Publications, 2019-05-22)
      Both intravenous thrombolysis with tissue plasminogen activator (IV-rtPA) and mechanical thrombectomy (MT) increase recanalization rates. We assessed if bridging-therapy (the concomitant use of rtPA and MT) could increase ...

    • Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry 

      Rossi, Rosanna; Molina, Sara; Mereuta, Oana Madalina; Douglas, Andrew; Fitzgerald, Seán; Tierney, Ciara; Pandit, Abhay; Brennan, Paul; Power, Sarah; O’Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Magoufis, Georgios; Tsivgoulis, Georgios; Nagy, András; Vadász, Ágnes; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dunker, Dennis; Carlqvist, Jeanette; Psychogios, Klearchos; Szikora, István; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Springer, 2021-08-20)
      Background and purpose There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT ...

    • Don't blame it all on antibodies--The need for exhaustive characterisation, appropriate handling, and addressing the issues that affect specificity 

      O'Kennedy, Richard; Fitzgerald, Seán; Murphy, Caroline (Elsevier, 2017-01-30)
      Recently there have been numerous very thought-provoking reports describing many issues relating to the overall quality of antibodies that are currently available. It appears that multiple major clinical and other analytical ...

    • Fatty acid binding protein expression in clots retrieved by mechanical thrombectomy from patients with acute ischaemic stroke 

      Mereuta, Oana Madalina; Fitzgerald, Seán; Douglas, Andrew; Rossi, Rosanna; Silva Santos, Andreia M.; Pandit, Abhay; Thornton, John; O'Hare, Alan; Power, Sarah; Brennan, Paul; Rentzos, Alexandros; Tatlisumak, Turgut; Gunnarsson, Thorsteinn; Davidson, Maria; Brederlau, Anke; Allardt, Arne; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Sage Publications, 2019-05-22)
      Introduction: Lipid accumulation and inflammation are considered hallmarks of the unstable atherosclerotic plaque. In particular, adipocyte fatty acid binding protein (FABP4) expression within the plaque is associated ...

    • High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer 

      Fitzgerald, Seán; Sheehan, Katherine M.; Espina, Virginia; O'Grady, Anthony; Cummins, Robert; Kenny, Dermot; Liotta, Lance; O'Kennedy, Richard; Kay, Elaine W.; Kijanka, Gregor S. (Wiley, 2014-11-13)
      Ceramide synthase 5 is involved in the de novo synthesis of ceramide, a sphingolipid involved in cell death and proliferation. In this study, we investigated the role of ceramide synthase 5 in colorectal cancer by examining ...

    • Histological characterization of white clots retrieved by mechanical thrombectomy from acute ischemic stroke patients 

      Mereuta, Oana Madalina; Fitzgerald, Seán; Douglas, Andy; Rossi, Rosanna; Silva Santos, Andreia M.; Pandit, Abhay; Thornton, John; Rentzos, Alexandros; Tatlisumak, Turgut; Doyle, Karen M. (SAGE Publications, 2019-01-01)
      Introduction: Advances in mechanical thrombectomy have created the unique opportunity to study the acute ischemic stroke clot material. However, there is a lack of uniformity in the histopathologic characterization of ...

    • Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations 

      Staessens, S.; Fitzgerald, Seán; Andersson, T.; Clarencon, F.; Denorme, F.; Gounis, M. J.; Hacke, W.; Liebeskind, D. S.; Szikora, I.; van Es, A. C. G. M.; Brinjikji, W.; Doyle, Karen M.; De Meyer, S. F. (SAGE Publications, 2019-11-03)
      The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus ...

    • The impact of occlusion location and bridging therapy in patients affected by acute ischemic stroke in determining the total number of passes required to remove the clot and the final revascularization outcome 

      Rossi, Rosanna; Fitzgerald, Seán; Mereuta, Oana Madalina; Douglas, Andrew; Pandit, Abhay; Szikora, István; Tsivgoulis, Georgios; Psychogios, Klearchos; Murphy, Blathnaid; Brennan, Paul; Power, Sarah; O'Hare, Alan; Thornton, John; Rentzos, Alexandros; Tatlisumak, Turgut; Doyle, Karen M. (WFITN (World Federation of Interventional and Therapeutic Neuroradiology), 2019-10-21)
      Purpose Our purpose was to assess the impact of occlusion location in patients suffering from Acute Ischemic Stroke (AIS) on the total number of passes (attempts) necessary to retrieve the clot and on final revascularization ...

    • Large artery atherosclerotic clots are larger than clots of other stroke etiologies and have poorer recanalization rates 

      Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Molina, Sara; Okolo, Adaobi; Douglas, Andrew; Jabrah, Duaa; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Jood, Katarina; Magoufis, Georgios; Psychogios, Klearchos; Tsivgoulis, Georgios; Alderson, Jack; O’Hare, Alan; Power, Sarah; Brennan, Paul; Nagy, András; Vadász, Ágnes; Brinjikji, Waleed; Kallmes, David; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Elsevier, 2020-11-24)
      Objectives There is a paucity of knowledge in the literature relating to the extent of clot burden and stroke etiology. In this study, we measured the Extracted Clot Area (ECA) retrieved during endovascular treatment (EVT) ...

    • Maximizing the catheter-to-vessel size optimizes distal flow control resulting in improved revascularization in vitro for aspiration thrombectomy 

      Nogueira, Raul G.; Ryan, David; Mullins, Liam; Thornton, John; Fitzgerald, Seán (BMJ Publishing Group, 2021-03-15)
      Background Balloon guide catheters (BGCs) achieve proximal flow control during thrombectomy but antegrade intracranial flow often persists via the Circle of Willis. Closely sizing an aspiration catheter to the target vessel ...

    • Novel human acute ischemic stroke blood clot analogs for in vitro thrombectomy testing 

      Fitzgerald, Seán; Liu, Yang; Dai, Daying; Mereuta, Oana Madalina; Abbasi, Mehdi; Larco, JL Arturo; Douglas, Andrew; Kallmes, David; Savastano, Luis; Doyle, Karen M.; Brinjikji, Waleed (American Society of Neuroradiology, 2021-04-08)
      BACKGROUND AND PURPOSE: Previous studies have successfully created blood clot analogs for in vitro endovascular device testing using animal blood of various species. Blood components vary greatly among species; therefore, ...

    • Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots 

      Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Murphree Jr, Dennis H.; Pandit, Abhay; Douglas, Andrew; Rizvi, Asim; Kadirvel, Ramanathan; Gilvarry, Michael; McCarthy, Ray; Stritt, Manuel; Gounis, Matthew J.; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Public Library of Science, 2019-12-05)
      Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical ...

    • Per pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted-clot-area and histological composition 

      Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Jabrah, Duaa; Okolo, Adaobi; Douglas, Andrew; Molina Gil, Sara; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Dunker, Dennis; Nordanstig, Annika; Ceder, Erik; Redfors, Petra; Jood, Katarina; Dehlfors, Niclas; Magoufis, Georgios; Tsivgoulis, Georgios; Brinjikji, Waleed; Kallmes, David F.; Hare, Alan; Power, Sarah; Brennan, Paul; Alderson, Jack; Nagy, András; Vadász, Ágnes; Psychogios, Klearchos; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (BMJ Publishing Group, 2020-12-09)
      Background Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic ...

    • Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT 

      Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Douglas, Andrew; Kadirvel, Ramanathan; Gounis, Matthew J.; Chueh, Juyu; Puri, Ajit S.; Layton, Kennith F.; Thacker, Ike C.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Almekhlafi, Mohammed A.; Demchuk, Andrew M.; Nogueira, Raul G.; Pereira, Vitor M.; Kvamme, Peter; Kayan, Yasha; Delgado Almandoz, Josser E.; Yoo, Albert J.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (BMJ Publishing Group, 2019-04-05)
      Background Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize ...

    • Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes 

      Douglas, Andrew; Fitzgerald, Seán; Mereuta, Oana Madalina; Rossi, Rosanna; O'Leary, Sean; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Holmegaard, Lukas; Abrahamsson, Margareta; Jerndal, Mikael; Dehlfors, Niclas; Brennan, Paul; Power, Sarah; O'Hare, Alan; Griffin, Emma; Kallmes, David F.; Brinjikji, Waleed; Szikora, István; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (BMJ Publishing Group, 2019-11-04)
      Background and aims Platelets and von Willebrand factor (vWF) are key factors in thrombosis and thus are likely key components of acute ischemic stroke (AIS) emboli. We aimed to characterize platelet and vWF levels in AIS ...

    • Platelet-rich emboli in cerebral large vessel occlusion are associated with a large artery atherosclerosis source 

      Fitzgerald, Seán; Dai, Daying; Wang, Shunli; Douglas, Andrew; Kadirvel, Ramanathan; Layton, Kennith F.; Thacker, Ike C.; Gounis, Matthew J.; Chueh, Ju-Yu; Puri, Ajit S.; Almekhlafi, Mohammed; Demchuk, Andrew M.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Yoo, Albert J.; Kvamme, Peter; Pereira, Vitor M.; Kayan, Yasha; Delgado Almandoz, Josser E.; Nogueira, Raul G.; Rabinstein, Alejandro A.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (American Heart Association, 2019-05-29)
      Background and Purpose— Nearly 30% of large vessel occlusion acute ischemic stroke clots are from an unknown source. We assessed histological clot composition in a series of patients with large vessel occlusion and ...

    • Preclinical evaluation of Millipede 088 intracranial aspiration catheter in cadaver and in vitro thrombectomy models 

      Fitzgerald, Seán; Ryan, David; Thornton, John; Nogueira, Raul G. (BMJ Publishing Group, 2020-06-30)
      Background Larger bore aspiration catheters are expected to significantly improve the speed and completeness of acute stroke revascularization. Objective To evaluate the navigability and clot retrieval performance of a ...