Browsing School of Medicine by Author "http://dx.doi.org/10.13039/501100007601"

Now showing items 1-11 of 11

    • Artificial cornea: Past, current, and future directions 

      Holland, Gráinne; Pandit, Abhay; Sánchez-Abella, Laura; Haiek, Andrea; Loinaz, Iraida; Dupin, Damien; Gonzalez, Maria; Larra, Eva; Bidaguren, Aritz; Lagali, Neil; Moloney, Elizabeth B.; Ritter, Thomas (Frontiers Media, 2021-11-12)
      Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal ...

    • Brain repair for Parkinson's disease: is the answer in the matrix? 

      Moriarty, Niamh; Dowd, Eilís (Medknow Publications, 2018-07-13)
      Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name, there is still an irrefutable need for a therapy that targets the underlying pathophysiology ...

    • EIT image-based bladder state classification for nocturnal enuresis 

      Dunne, Eoghan; Santorelli, Adam; McGinley, Brian; O'Halloran, Martin; Leader, Geraldine; Porter, Emily (School of Engineering, The University of Edinburgh, 2018-06-11)
      In this paper, we propose the use of electrical impedance tomography (EIT) to support children with nocturnal enuresis. We perform the first image-based threshold classification for determining the bladder state of not ...

    • Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations 

      Staessens, S.; Fitzgerald, Seán; Andersson, T.; Clarencon, F.; Denorme, F.; Gounis, M. J.; Hacke, W.; Liebeskind, D. S.; Szikora, I.; van Es, A. C. G. M.; Brinjikji, W.; Doyle, Karen M.; De Meyer, S. F. (SAGE Publications, 2019-11-03)
      The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus ...

    • Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies 

      Wang, Jiemin; Donohoe, Ellen; Canning, Aoife; Moosavizadeh, Seyedmohammad; Buckley, Fiona; Brennan, Meadhbh Á.; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2023-10-23)
      Background Mesenchymal stromal cells (MSCs) show great potential for immunomodulatory and anti-inflammatory treatments. Clinical trials have been performed for the treatment of Type 1 diabetes, graft-versus-host disease ...

    • Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's disease. 

      Hertel, Johannes; Harms, Amy C.; Heinken, Almut; Baldini, Federico; Thinnes, Cyrille C; Glaab, Enrico; Vasco, Daniel A.; Pietzner, Maik; Stewart, Isobel D.; Wareham, Nicholas J.; Langenberg, Claudia; Trenkwalder, Claudia; Krüger, Rejko; Hankemeier, Thomas; Fleming, Ronan M. T.; Mollenhauer, Brit; Thiele, Ines (Elsevier, 2019-11-12)
      Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched ...

    • Integrated in vitro and in silico modelling delineates the molecular effects of a synbiotic regimen on colorectal cancer-derived cells 

      Greenhalgh, Kacy; Ramiro-Garcia, Javier; Heinken, Almut; Ullmann, Pit; Bintener, Tamara; Pires Pacheco, Maria; Baginska, Joanna; Shah, Pranjul; Frachet, Audrey; Halder, Rashi; Fritz, Joëlle V.; Sauter, Thomas; Thiele, Ines; Haan, Serge; Letellier, Elisabeth; Wilmes, Paul (Cell Press, 2019-04-30)
      By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as colorectal cancer (CRC). Methodological limitations have prevented ...

    • A longitudinal survey of antibiotic-resistant enterobacterales in the Irish environment, 2019–2020 

      Hooban, Brigid; Fitzhenry, Kelly; O'Connor, Louise; Miliotis, Georgios; Joyce, Aoife; Chueiri, Alexandra; Farrell, Maeve Louise; DeLappe, Niall; Tuohy, Alma; Cormican, Martin; Morris, Dearbháile (Elsevier, 2022-03-17)
      The natural environment represents a complex reservoir of antibiotic-resistant bacteria as a consequence of different wastewater discharges including anthropogenic and agricultural. Therefore, the aim of this study was to ...

    • Maximizing the catheter-to-vessel size optimizes distal flow control resulting in improved revascularization in vitro for aspiration thrombectomy 

      Nogueira, Raul G.; Ryan, David; Mullins, Liam; Thornton, John; Fitzgerald, Seán (BMJ Publishing Group, 2021-03-15)
      Background Balloon guide catheters (BGCs) achieve proximal flow control during thrombectomy but antegrade intracranial flow often persists via the Circle of Willis. Closely sizing an aspiration catheter to the target vessel ...

    • Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice 

      Treacy, Oliver; Lynch, Kevin; Murphy, Nick; Chen, Xizhe; Donohoe, Ellen; Canning, Aoife; Lohan, Paul; Shaw, Georgina; Fahy, Gerry; Ryan, Aideen E.; Ritter, Thomas (BMC, 2021-04-06)
      Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ...

    • Third-party allogeneic mesenchymal stromal cells prevent rejection in a pre-sensitized high-risk model of corneal transplantation 

      Lohan, Paul; Murphy, Nick; Treacy, Oliver; Lynch, Kevin; Morcos, Maurice; Bingling, Chen; Ryan, Aideen E.; Griffin, Matthew D.; Ritter, Thomas (Frontiers Media, 2018-11-20)
      High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. ...