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Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: Are we still learning?
(Frontiers Media, 2017-11-24)
Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppr ...
Shiga toxigenic Escherichia coli incidence is related to small area variation in cattle density in a region in Ireland
(Elsevier, 2018-05-12)
Shiga toxigenic Escherichia coli (STEC) are pathogenic E. coli that cause infectious diarrhoea. In some cases infection may be complicated by renal failure and death. The incidence of human infection with STEC in Ireland ...
Strength in Numbers: an international consensus conference to develop a novel approach to care delivery for young adults with type 1 diabetes, the D1 Now Study
(BioMed Central, 2017-12-04)
Many young adults with type 1 diabetes struggle with the day-to-day management of their condition. They often find it difficult to find the time to attend their clinic appointments and to meet with their diabetes healthcare ...
Extracellular vesicles as modulators of wound healing
(Elsevier, 2018-01-31)
Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been ...
Third-party allogeneic mesenchymal stromal cells prevent rejection in a pre-sensitized high-risk model of corneal transplantation
(Frontiers Media, 2018-11-20)
High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. ...
Indistinguishable NDM-producing escherichia coli isolated from recreational waters, sewage, and a clinical specimen in Ireland, 2016 to 2017
(European Centre for Disease Prevention and Control, 2017-04-13)
In this study, New Delhi metallo-beta-lactamase (NDM)-producing Enterobacteriaceae were identified in Irish recreational waters and sewage. Indistinguishable NDM-producing Escherichia coli by pulsed-field gel electrophoresis ...
vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis
(2016-05-18)
Recent efforts in osteoarthritis (OA) research have highlighted synovial inflammation and involvement of immune cells in disease onset and progression. We sought to establish the in-vivo immune response in collagenase-induced ...
Gender-specific abnormalities in the serotonin transporter system in panic disorder
(Cambridge University Press, 2013)
The central serotonergic system has been implicated in the pathophysiology of panic disorder (PD) by evidence of abnormally elevated serotonin-turnover, reduced pre- and post-synaptic 5-HT(1A-)receptor sensitivity and ...
Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [C-11]DASB
(2010)
In a previous study we showed that genetic variation in HTR2A, which encodes the serotonin 2A receptor, influenced outcome of citalopram treatment in patients with major depressive disorder. Since chronic administration ...
Medical speciality choices: Does personality matter?
(Irish Medical Journal, 2015-08-07)
There has been
increasing interest in the personalities of doctors. This study examined
whether personality differed based upon gender, level of training or medical
speciality among 200 physicians and 134 medical students. ...