Browsing Medicine by Author "http://dx.doi.org/10.13039/501100002081"
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Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly
Xu, Maojia; Stattin, Eva-Lena; Shaw, Georgina; Heinegård, Dick; Sullivan, Gareth; Wilmut, Ian; Colman, Alan; Önnerfjord, Patrik; Khabut, Areej; Aspberg, Anders; Dockery, Peter; Hardingham, Timothy; Murphy, Mary; Barry, Frank (Wiley, 2016-07-07)Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is ... -
Shiga toxigenic Escherichia coli incidence is related to small area variation in cattle density in a region in Ireland
Brehony, Carina; Cullinan, John; Cormican, Martin; Morris, D. (Elsevier, 2018-05-12)Shiga toxigenic Escherichia coli (STEC) are pathogenic E. coli that cause infectious diarrhoea. In some cases infection may be complicated by renal failure and death. The incidence of human infection with STEC in Ireland ... -
Stromal cell PD-L1iInhibits CD8(+) T-cell antitumor immune responses and promotes colon cancer
O'Malley, Grace; Treacy, Oliver; Lynch, Kevin; Naicker, Serika D.; Leonard, Niamh A.; Lohan, Paul; Dunne, Philip D.; Ritter, Thomas; Egan, Laurence J.; Ryan, Aideen E. (American Association for Cancer Research, 2018-11)Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as ... -
Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
Treacy, Oliver; Lynch, Kevin; Murphy, Nick; Chen, Xizhe; Donohoe, Ellen; Canning, Aoife; Lohan, Paul; Shaw, Georgina; Fahy, Gerry; Ryan, Aideen E.; Ritter, Thomas (BMC, 2021-04-06)Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ...