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Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery – a pilot study
(Wiley, 2019-11-07)
Diabetes mellitus (DM) is associated with an elevated risk of post-operative complications. The impact it has on patients living with DM following hip fracture surgery (HFS) is not completely understood, and may represent ...
Non-viral xylosyltransferase-1 siRNA delivery as an effective alternative to chondroitinase in an in vitro model of reactive astrocytes
(Elsevier, 2016-10-13)
Reactive astrocytosis and the subsequent glial scar is ubiquitous to injuries of the central nervous system, especially spinal cord injury (SCI) and primarily serves to protect against further damage, but is also a prominent ...
Brain repair for Parkinson's disease: is the answer in the matrix?
(Medknow Publications, 2018-07-13)
Two hundred years after James Parkinson first described the cardinal
motor symptoms of the disorder that would later bear his name, there
is still an irrefutable need for a therapy that targets the underlying
pathophysiology ...
Central CB2 receptors in inflammation-driven neurodegeneration: dysregulation and therapeutic potential
(Medknow Publications, 2016-10-19)
In recent times there has been an intensification of interest in the pathological role of neuroinflammation in neurodegenerative disease. Neuroprotective strategies to slow, halt or reverse neurodegeneration have not proven ...
The search for understanding: the role of paradigms
(RCN Publishing, 2017-05-22)
The aim of this paper is to add to discussions on the role of paradigmatic worldviews when
planning for a research study. An understanding of paradigmatic developmental trajectories
is necessary when planning a study and ...
Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in pain and psychiatric disorders
(Karger, 2015)
The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for ...
Health and well-being in social care workers
(Women's Studies Centre, NUI Galway, 1998)
[No abstract available]
Balancing perspectives on intervention feasibility: using stakeholder views in decision-making
(BMJ Publishing Group, 2019-03-20)
Background Anxiety and stress are prevalent in general practice and primary care settings, particularly among women. The ‘Redesigning Daily Occupations’ (ReDO) programme is a manualised occupational therapy-led intervention ...
The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
(Wiley, 2018-05-30)
Background and Purpose
The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ...