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Alterations in the central opioid system following acute swim stress and olfactory bulbectomy in the rat
(Elsevier, 2019-12-13)
Introduction: Stress is a major component of many animal models of depression, induced acutely as in the forced swim test, or more long-term in the olfactory bulbectomy (OB) and chronic mild stress models [1]. The central ...
Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain
(De Gruyter, 2016-01-01)
Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural mechanisms involved are poorly understood. Chronic pain is associated with changes in synaptic plasticity in the brain which ...
N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism
(Lippincott, Williams & Wilkins, 2016-12)
The neural substrates and mechanisms mediating the antinociceptive effects of the endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation. We investigated the effects of exogenous PEA ...
The development of translational biomarkers as a tool for improving the understanding, diagnosis and treatment of chronic neuropathic pain
(Springer, 2017-03-30)
Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods ...
Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat
(Elsevier, 2016-08-31)
Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress ...
Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
(SAGE Publications, 2019-09-12)
Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ...
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders
(Elsevier, 2015-03-17)
Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects ...
Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid
(Elsevier, 2016-08-31)
Autism spectrum disorders are a group of neurodevelopmental disorders characterised by impaired social interaction, deficits in communication and repetitive stereotyped behaviours. The endocannabinoid system plays an ...
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
(Wiley, 2016-07-12)
A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases ...
Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli
(International Association for the Study of Pain, 2014-01)
Pain is both a sensory and an emotional experience, and is subject to modulation by a number of factors including genetic background modulating stress/affect. The Wistar-Kyoto (WKY) rat exhibits a stress-hyper-responsive ...