Search
Now showing items 341-350 of 513
Central CB2 receptors in inflammation-driven neurodegeneration: dysregulation and therapeutic potential
(Medknow Publications, 2016-10-19)
In recent times there has been an intensification of interest in the pathological role of neuroinflammation in neurodegenerative disease. Neuroprotective strategies to slow, halt or reverse neurodegeneration have not proven ...
The search for understanding: the role of paradigms
(RCN Publishing, 2017-05-22)
The aim of this paper is to add to discussions on the role of paradigmatic worldviews when
planning for a research study. An understanding of paradigmatic developmental trajectories
is necessary when planning a study and ...
Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in pain and psychiatric disorders
(Karger, 2015)
The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for ...
Cannabinoids and pain: sites and mechanisms of action
(Elsevier, 2017-06-20)
The endocannabinoid system, consisting of the cannabinoid(1) receptor (CB1R) and cannabinoid(2) receptor (CB2R), endogenous cannabinoid ligands (endocannabinoids), and metabolizing enzymes, is present throughout the pain ...
Balancing perspectives on intervention feasibility: using stakeholder views in decision-making
(BMJ Publishing Group, 2019-03-20)
Background Anxiety and stress are prevalent in general practice and primary care settings, particularly among women. The ‘Redesigning Daily Occupations’ (ReDO) programme is a manualised occupational therapy-led intervention ...
The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
(Wiley, 2018-05-30)
Background and Purpose
The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ...
Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats
(Elsevier, 2018-12-13)
Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial mu-opioid receptor (MOR) agonist and ...
Telling a ‘good or white lie’: The views of people living with dementia and their carers
(SAGE Publications, 2019-02-25)
Objective: A common symptom of cognitive decline in people living with dementia, or people
with memory problems, the cause of which has not yet been diagnosed, is the person repeatedly
asking for loved ones who are ...
Exploring registered psychiatric nurses responses towards service users with a diagnosis of borderline personality disorder
(Hindawi Publishing Corporation, 2012-01-25)
This study explored registered psychiatric nurses' (RPNs') interactions and level of empathy towards service users with a diagnosis of borderline personality disorder (BPD). A qualitative approach was used, and 17 RPNs ...
Research approaches related to phenomenology: negotiating a complex landscape
(RCN Publishing, 2011-10-21)
Aim To provide a comprehensive overviev\/ of the
many research approaches related fo phenomenology
and their philosophical underpinnings.
Background Phenomenological research approaches
are varied and often difficult ...