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The tensile ductility of cellular solids: the role of imperfections
(Elsevier, 2016-10-11)
Metallic and polymeric foams typically possess a low tensile failure strain of a few percent despite the fact that the parent solid can have high ductility (10% or more). This is remarkable as foams are bending-dominated ...
Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions
(Elsevier, 2014-11-27)
We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces ...
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
(Elsevier, 2014-02-11)
Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ...
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
(Elsevier, 2012-12-24)
Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ...
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
(The Royal Society Publishing, 2012-07-18)
The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ...
Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds
(Elsevier, 2015-09-02)
Scaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational ...
Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells
(Elsevier ScienceDirect, 2012-06-21)
Numerous in-vitro studies have established that cells react to their physical environment and to applied mechanical loading. However, the mechanisms underlying such phenomena are poorly understood. Previous modelling of ...
A thermodynamically motivated model for stress-fiber reorganization
(Springer Verlag, 2015-09-04)
We present a model for stress-fiber reorganization and the associated contractility that includes both the kinetics of stress-fiber formation and dissociation as well as the kinetics of stress-fiber remodeling. These ...
Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
(Springer Verlag, 2013-06-18)
Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ...
Experimental and computational investigation of the role of stress fiber contractility in the resistance of osteoblasts to compression
(2013)
The mechanical behavior of the actin cytoskeleton has previously been investigated using both experimental and computational techniques. However, these investigations have not elucidated the role the cytoskeleton plays in ...