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Mechanisms of osteocyte stimulation in osteoporosis
(Elsevier, 2016-05-10)
Experimental studies have shown that primary osteoporosis' caused by oestrogen deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular ...
Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach
(Springer Verlag, 2013-04-09)
Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental ...
A combined experimental-numerical approach for generating statistically equivalent fibre distributions for high strength laminated composite materials
(Elsevier, 2009-11-04)
A technique is presented where actual experimental distributions, measured from a high strength carbon fibre composite, are considered in the development of a novel method to generate statistically equivalent fibre ...
Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal
(Elsevier, 2015-01-14)
Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the ...
Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
(Wiley, 2013-12-03)
Bone continuously adapts its internal structure to accommodate the
functional demands of its mechanical environment. This process is
orchestrated by a network of mechanosensitive osteocytes that respond to
external ...
Evaluation of a multiscale modelling methodology to predict the mechanical properties of PCL/β-TCP sintered scaffold materials
(Springer Verlag, 2014-12-02)
A multiscale modelling methodology to predict the macroscale stiffness of selective laser sintered polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) materials is evaluated. The relationship between a micromechanics-evaluated ...
An investigation of the inelastic behaviour of trabecular bone during the press-fit implantation of a tibial component in total knee arthroplasty
(Institute of Physics and Engineering in Medicine by Elsevier Ltd., 2013)
The stress distribution and plastic deformation of peri-prosthetic trabecular bone during press-fit tibial component implantation in total knee arthroplasty is investigated using experimental and finite element techniques. ...
Improving the finite element model accuracy of tissue engineered scaffolds produced by selective laser sintering
(Springer Verlag, 2015-01-13)
In bone tissue engineering, both geometrical and mechanical properties of a scaffold play a major part in the success of the treatment. The mechanical stresses and strains that act on cells on a scaffold in a physiological ...
A physical corrosion model for bioabsorbable metal stents
(2014)
Absorbable metal stents (AMSs) are an emerging technology in the treatment of heart disease. Computational modelling of AMS performance will facilitate the development of this technology. In this study a physical corrosion ...