Improving the finite element model accuracy of tissue engineered scaffolds produced by selective laser sintering
McHugh, Peter E.
MetadataShow full item record
This item's downloads: 73 (view details)
Lohfeld, S., Cahill, S., Doyle, H., & McHugh, P. E. (2015). Improving the finite element model accuracy of tissue engineering scaffolds produced by selective laser sintering. Journal of Materials Science: Materials in Medicine, 26(1), 1-12. doi: 10.1007/s10856-014-5376-0
In bone tissue engineering, both geometrical and mechanical properties of a scaffold play a major part in the success of the treatment. The mechanical stresses and strains that act on cells on a scaffold in a physiological environment are a determining factor on the subsequent tissue formation. Computational models are often used to simulate the effect of changes of internal architectures and external loads applied to the scaffold in order to optimise the scaffold geometry for the prospective implantation site. Finite element analysis (FEA) based on computer models of the scaffold is a common technique, but would not take into account actual inaccuracies due to the manufacturing process. Image based FEA using CT scans of fabricated scaffolds can provide a more accurate analysis of the scaffold, and was used in this work in order to accurately simulate and predict the mechanical performance of bone tissue engineering scaffolds, fabricated using selective laser sintering (SLS), with a view to generating a methodology that could be used to optimise scaffold design. The present work revealed that an approach that assumes iso- tropic properties of SLS fabricated scaffolds will lead to inaccurate predictions of the FE model. However, a dependency of the greyvalue of the CT scans and the mechanical properties was discovered, which may ultimately lead to accurate FE models without the need of experimental validation.
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
The role of matrix properties and extrinsic loading in osteoblast-osteocyte differentiation in tissue engineered scaffolds Mc Garrigle, Myles (2018-02-05)Bone tissue engineering is a promising field with the potential to generate tissue substitutes, by taking advantage of mesenchymal stem cells ability to grow and produce tissue substitutes under specific physical conditions. ...
Investigations into assimilating high-frequency radar data into a three-dimensional hydrodynamic model of a wind-dominated coastal water body Ren, Lei (2015-10)Accurate forecasting of surface currents in coastal waters is of great importance for operations such as search and rescue operations and marine energy extraction. Numerical models and measurements are two powerful ...
Evaluation of a multiscale modelling methodology to predict the mechanical properties of PCL/β-TCP sintered scaffold materials Doyle, Heather; Lohfeld, Stefan; McDonnell, Pat; McHugh, Peter E. (Springer Verlag, 2014-12-02)A multiscale modelling methodology to predict the macroscale stiffness of selective laser sintered polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) materials is evaluated. The relationship between a micromechanics-evaluated ...