dc.contributor.author | Shirazi, Reyhaneh Neghabat | |
dc.contributor.author | Aldabbagh, Fawaz | |
dc.contributor.author | Ronan, William | |
dc.contributor.author | Erxleben, Andrea | |
dc.contributor.author | Rochev, Yury | |
dc.contributor.author | McHugh, Peter | |
dc.date.accessioned | 2016-10-03T13:05:26Z | |
dc.date.issued | 2016-09-02 | |
dc.identifier.citation | Shirazi, Reyhaneh Neghabat, Aldabbagh, Fawaz, Ronan, William, Erxleben, Andrea, Rochev, Yury, & McHugh, Peter. (2016). Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance. Journal of Materials Science: Materials in Medicine, 27(10), 1-12. doi: 10.1007/s10856-016-5760-z | en_IE |
dc.identifier.issn | 1573-4838 | |
dc.identifier.uri | http://hdl.handle.net/10379/6046 | |
dc.description.abstract | In this study, the effects of material thickness and processing method on the degradation rate and the changes in the mechanical properties of poly(lactic-co-glycolic acid) material during simulated physiological degradation were investigated. Two types of poly(lactic-co-glycolic acid) materials were considered: 0.12¿mm solvent-cast films and 1¿mm compression-moulded plates. The experimental results presented in this study were compared to the experimental results of Shirazi et al. (Acta Biomaterialia 10(11):4695-703, 2014) for 0.25¿mm solvent-cast films. These experimental observations were used to validate the computational modelling predictions of Shirazi et al. (J Mech Behav Biomed Mater 54: 48-59, 2016) on critical diffusion length scale and also to refine the model parameters. The specific material processing methods considered here did not have a significant effect on the degradation rate and the changes in mechanical properties during degradation; however, they influenced the initial molecular weight and they determined the stiffness and hardness of the poly(lactic-co-glycolic acid) material. The experimental observations strongly supported the computational modelling predictions that showed no significant difference in the degradation rate and the changes in the elastic modulus of poly(lactic-co-glycolic acid) films for thicknesses larger than 100¿¿m. | en_IE |
dc.description.sponsorship | Funding support was provided by the Structured PhD Programme in Biomedical Engineering and Regenerative Medicine
(BMERM), funded under the Programme for Research in ThirdLevel Institutions (PRTLI) Cycle 5 and co-funded under the European Regional Development Fund (ERDF). | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Springer Verlag | en_IE |
dc.relation.ispartof | Journal Of Materials Science-Materials In Medicine | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Poly(lactic-coglycolic acid) | en_IE |
dc.subject | Materials | en_IE |
dc.subject | Thickness | en_IE |
dc.subject | Mechanical engineering | en_IE |
dc.title | Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2016-09-29T15:11:52Z | |
dc.identifier.doi | 10.1007/s10856-016-5760-z | |
dc.local.publishedsource | http://dx.doi.org/10.1007/s10856-016-5760-z | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | |~| | |
dc.description.embargo | 2017-09-02 | |
dc.internal.rssid | 11400520 | |
dc.local.contact | William Ronan, Mechanical Engineering, School Of Engineering, Nui Galway. Email: william.ronan@nuigalway.ie | |
dc.local.copyrightchecked | No | |
dc.local.version | ACCEPTED | |
nui.item.downloads | 679 | |