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dc.contributor.authorRonan, William
dc.contributor.authorMcMeeking, Robert M.
dc.contributor.authorChen, Christopher S.
dc.contributor.authorDeshpande, Vikram S.
dc.date.accessioned2016-08-09T14:01:12Z
dc.date.available2016-08-09T14:01:12Z
dc.date.issued2014-11-27
dc.identifier.citationRonan, William, McMeeking, Robert M., Chen, Christopher S., McGarry, J. Patrick, & Deshpande, Vikram S. (2015). Cooperative contractility: The role of stress fibres in the regulation of cell-cell junctions. Journal of Biomechanics, 48(3), 520-528. doi: http://dx.doi.org/10.1016/j.jbiomech.2014.11.025en_IE
dc.identifier.issn1873-2380
dc.identifier.urihttp://hdl.handle.net/10379/5935
dc.description.abstractWe present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces exerted by the cell and these show that the cell-cell tugging stress is a constant and independent of the cell-cell junction area. In the current study, we demonstrate that a material model which includes the underlying cellular processes of stress fibre contractility and adhesion formation can capture these results. The simulations explain the experimentally observed phenomena whereby the cell-cell junction forces increase with junction size but the tractions exerted by the cell on the micro-post array are independent of the junction size. Further simulations on different types of micro-post arrays and cell phenotypes are presented as a guide to future experiments. (C) 2014 Elsevier Ltd. All rights reserved.en_IE
dc.description.sponsorshipScience Foundation Ireland grant 10/RFP/ENM2960 and Short Term Travel Fellowship (STTF 11)en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofJournal Of Biomechanicsen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectMechanotransductionen_IE
dc.subjectStress fibreen_IE
dc.subjectJunction forceen_IE
dc.subjectMyosin contractilityen_IE
dc.subjectCell-cell junctionsen_IE
dc.subjectMechanical modelen_IE
dc.subjectCytoskeletonen_IE
dc.subjectSubstrateen_IE
dc.subjectElasticityen_IE
dc.subjectSimulationen_IE
dc.subjectTensegrityen_IE
dc.subjectStiffnessen_IE
dc.subjectForceen_IE
dc.subjectMechanical engineeringen_IE
dc.titleCooperative contractility: the role of stress fibres in the regulation of cell-cell junctionsen_IE
dc.typeArticleen_IE
dc.date.updated2016-07-29T14:58:33Z
dc.identifier.doi10.1016/j.jbiomech.2014.11.025
dc.local.publishedsourcehttp:/dx.doi.org/10.1016/j.jbiomech.2014.11.025en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid8544363
dc.local.contactWilliam Ronan, Mechanical Engineering, School Of Engineering, Nui Galway. Email: william.ronan@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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