dc.contributor.author | Ronan, William | |
dc.contributor.author | McMeeking, Robert M. | |
dc.contributor.author | Chen, Christopher S. | |
dc.contributor.author | Deshpande, Vikram S. | |
dc.date.accessioned | 2016-08-09T14:01:12Z | |
dc.date.available | 2016-08-09T14:01:12Z | |
dc.date.issued | 2014-11-27 | |
dc.identifier.citation | Ronan, William, McMeeking, Robert M., Chen, Christopher S., McGarry, J. Patrick, & Deshpande, Vikram S. (2015). Cooperative contractility: The role of stress fibres in the regulation of cell-cell junctions. Journal of Biomechanics, 48(3), 520-528. doi: http://dx.doi.org/10.1016/j.jbiomech.2014.11.025 | en_IE |
dc.identifier.issn | 1873-2380 | |
dc.identifier.uri | http://hdl.handle.net/10379/5935 | |
dc.description.abstract | We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces exerted by the cell and these show that the cell-cell tugging stress is a constant and independent of the cell-cell junction area. In the current study, we demonstrate that a material model which includes the underlying cellular processes of stress fibre contractility and adhesion formation can capture these results. The simulations explain the experimentally observed phenomena whereby the cell-cell junction forces increase with junction size but the tractions exerted by the cell on the micro-post array are independent of the junction size. Further simulations on different types of micro-post arrays and cell phenotypes are presented as a guide to future experiments. (C) 2014 Elsevier Ltd. All rights reserved. | en_IE |
dc.description.sponsorship | Science Foundation Ireland grant 10/RFP/ENM2960 and Short Term Travel Fellowship (STTF 11) | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Elsevier | en_IE |
dc.relation.ispartof | Journal Of Biomechanics | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Mechanotransduction | en_IE |
dc.subject | Stress fibre | en_IE |
dc.subject | Junction force | en_IE |
dc.subject | Myosin contractility | en_IE |
dc.subject | Cell-cell junctions | en_IE |
dc.subject | Mechanical model | en_IE |
dc.subject | Cytoskeleton | en_IE |
dc.subject | Substrate | en_IE |
dc.subject | Elasticity | en_IE |
dc.subject | Simulation | en_IE |
dc.subject | Tensegrity | en_IE |
dc.subject | Stiffness | en_IE |
dc.subject | Force | en_IE |
dc.subject | Mechanical engineering | en_IE |
dc.title | Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2016-07-29T14:58:33Z | |
dc.identifier.doi | 10.1016/j.jbiomech.2014.11.025 | |
dc.local.publishedsource | http:/dx.doi.org/10.1016/j.jbiomech.2014.11.025 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | |~| | |
dc.internal.rssid | 8544363 | |
dc.local.contact | William Ronan, Mechanical Engineering, School Of Engineering, Nui Galway. Email: william.ronan@nuigalway.ie | |
dc.local.copyrightchecked | No | |
dc.local.version | ACCEPTED | |
nui.item.downloads | 293 | |