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dc.contributor.authorShirazi, Reyhaneh Neghabat
dc.contributor.authorRonan, William
dc.contributor.authorRochev, Yury
dc.contributor.authorMcHugh, Peter
dc.date.accessioned2016-08-09T13:21:55Z
dc.date.issued2015-09-02
dc.identifier.citationShirazi, RN,Ronan, W,Rochev, Y,McHugh, P (2016) 'Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds'. Journal Of The Mechanical Behavior Of Biomedical Materials, 54 :48-59.en_IE
dc.identifier.issn1878-0180
dc.identifier.urihttp://hdl.handle.net/10379/5933
dc.description.abstractScaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational investigation of the molecular weight degradation and the mechanical performance of poly(lactic-co-glycolic acid) (PLGA) films and tissue engineering scaffolds. A reaction-diffusion model which predicts the degradation behaviour is coupled with an entropy based mechanical model which relates Young's modulus and the molecular weight. The model parameters are determined based on experimental data for in-vitro degradation of a PLGA film. Microstructural models of three different scaffold architectures are used to investigate the degradation and mechanical behaviour of each scaffold. Although the architecture of the scaffold does not have a significant influence on the degradation rate, it determines the initial stiffness of the scaffold. It is revealed that the size of the scaffold strut controls the degradation rate and the mechanical collapse. A critical length scale due to competition between diffusion of degradation products and autocatalytic degradation is determined to be in the range 2-100 mu m. Below this range, slower homogenous degradation occurs; however, for larger samples monomers are trapped inside the sample and faster autocatalytic degradation occurs. (C) 2015 Elsevier Ltd. All rights reserved.en_IE
dc.description.sponsorshipFunding support was provided by the Structured PhD Programme in Biomedical Engineering and Regenerative Medicine (BMERM). Funded under the Programme for Research in Third-Level Institutions (PRTLI) Cycle 5 (Strand 2) and co-funded under the European Regional Development Fund (ERDF).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofJournal Of The Mechanical Behavior Of Biomedical Materialsen
dc.subjectPLGAen_IE
dc.subjectDegradationen_IE
dc.subjectFinite element modellingen_IE
dc.subjectTissue engineering scaffolden_IE
dc.subjectMechanical propertiesen_IE
dc.subjectSize effecten_IE
dc.subjectMechanical engineeringen_IE
dc.subjectPhosphate buffer solutionen_IE
dc.subjectIn-vitro degradationen_IE
dc.subjectHydrolytic degradationen_IE
dc.subjectBiodegradable polymersen_IE
dc.subjectPLGA microspheresen_IE
dc.subjectPorous scaffoldsen_IE
dc.subjectVivo degradationen_IE
dc.subjectCast filmsen_IE
dc.titleModelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffoldsen_IE
dc.typeArticleen_IE
dc.date.updated2016-07-29T14:57:24Z
dc.identifier.doi10.1016/j.jmbbm.2015.08.030
dc.local.publishedsourcehttp:/dx.doi.org/doi:10.1016/j.jmbbm.2015.08.030en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.description.embargo2017-09-02
dc.internal.rssid10620133
dc.local.contactWilliam Ronan, Mechanical Engineering, School Of Engineering, Nui Galway. Email: william.ronan@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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