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Now showing items 21-25 of 25
Adverse early life experiences are associated with changes in pressure and cold pain sensitivity in young adults
(AME Publishing, 2020-07)
[No abstract available]
Pharmacological blockade of PPARα exacerbates inflammatory pain-related impairment of spatial memory in rats
(MDPI, 2021-05-27)
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPAR¿, PPARß/¿ and PPAR¿. Studies suggest that the PPAR signalling system may modulate pain, ...
Exacerbated LPS/GalN-induced liver injury in the stress-sensitive Wistar Kyoto rat is associated with changes in the endocannabinoid system
(MDPI, 2020-08-23)
Acute liver injury (ALI) is a highly destructive and potentially life-threatening condition, exacerbated by physical and psychological stress. The endocannabinoid system plays a key role in modulating stress and hepatic ...
A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats
(Wiley, 2013-12-05)
Background and Purpose
The nuclear hormone receptor, PPARα, and its endogenous ligands, are involved in pain modulation. PPARα is expressed in the medial prefrontal cortex (mPFC), a key brain region involved in both the ...
Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats
(Elsevier, 2020-05-30)
The influence of parental support on child pain experiences is well recognised. Accordingly, animal studies have revealed both short- and long-term effects of early life stress on nociceptive responding and neural substrates ...