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Effect of sodium glucose co-transporter-2 inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus

Griffin, Tomás P.; Islam, Md Nahidul; Blake, Liam; Bell, Marcia; Griffin, Matthew D.; O’Shea, Paula M. (Thieme Publishing, 2018-12-06)

The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of ...

Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers

Islam, Md Nahidul; Griffin, Tomás P.; Sander, Elizabeth; Rocks, Stephanie; Qazi, Junaid; Cabral, Joana; McCaul, Jasmin; McMorrow, Tara; Griffin, Matthew D. (BMC, 2019-11-19)

Background: Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study ...