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Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint
(Company of Biologists, 2016)
During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase ...
Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation
(2012)
Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential which makes them attractive targets for regenerative medicine applications. However, to date, therapeutic success of MSC-therapy ...
Laser sintering for the fabrication of tissue engineering scaffolds
(Springer Science+Business Media, 2012)
Laser sintering (LS) utilises a laser to sinter powder particles. A volumetric model is sliced and processedcross section by cross section to create a physical part. In theory, all powdered materials are suitable forsintering; ...
Predicting the elastic properties of selective laser sintered PCL/b-TCP bone scaffold materials using computational modelling.
(Springer, 2013)
Abstract This study assesses the ability of finite element (FE) models to capture the mechanical behaviour of sintered orthopaedic scaffold materials. Individual scaffold struts were fabricated from a 50:50 wt% ...
Immunogenicity of allogeneic mesenchymal stem cells
(2012)
Mesenchymal stem cells (MSCs) inhibit proliferation of allogeneic T cells and express low levels of major histocompatibility complex class I (MHCI), MHCII and vascular adhesion molecule-1 (VCAM-1). We investigated whether ...
Interaction of cell culture with composition effects on the mechanical properties of polycaprolactone-hydroxyapatite scaffolds fabricated via selective laser sintering (SLS)
(Elsevier, 2012)
In the current study PCL/HA composites were fabricated using SLS as two- and three-dimensional lattice structures and exposed to a cellular component (MC 313 osteoblast-like cells). The main aims were to determine the ...
Effects of combined progesterone and beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
(American Physiological Society, 2015)
A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed in order to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that ...
Implications of the UK HGV road user charge for Irish export freight transport stakeholders. A qualitative study
(Elsevier, 2016-04-13)
Road user charging in the European Union has evolved from a mechanism of financing the construction and maintenance of motorways to internalising the road user costs in line with the polluter pays principle. The United ...
The creative edge policy toolkit: from growth to dustainability: supporting the development of the creative economy in Europe’s northern periphery
(Creative Edge, 2013)
The concept of the creative economy first emerged in the mid-1980s in response to a crisis brought about by the decline in manufacturing in many of the world’s most developed economies. The idea suggests a productive ...
Targeting online communities to maximise information diffusion
(Association for Computing Machinery, 2012-04)
In recent years, many companies have started to utilise online social communities as a means of communicating with and targeting their employees and customers. Such online communities include discussion fora which are ...