dc.contributor.author | Staessens, Senna | |
dc.contributor.author | François, Olivier | |
dc.contributor.author | Brinjikji, Waleed | |
dc.contributor.author | Doyle, Karen M. | |
dc.contributor.author | Vanacker, Peter | |
dc.contributor.author | Andersson, Tommy | |
dc.contributor.author | De Meyer, Simon F. | |
dc.date.accessioned | 2022-03-28T08:08:24Z | |
dc.date.available | 2022-03-28T08:08:24Z | |
dc.date.issued | 2021-09-14 | |
dc.identifier.citation | Staessens, Senna, François, Olivier, Brinjikji, Waleed, Doyle, Karen M., Vanacker, Peter, Andersson, Tommy, & Meyer, Simon F. De. (2021). Studying Stroke Thrombus Composition After Thrombectomy: What Can We Learn? Stroke, 52(11), 3718-3727. doi:doi:10.1161/STROKEAHA.121.034289 | en_IE |
dc.identifier.issn | 1524-4628 | |
dc.identifier.uri | http://hdl.handle.net/10379/17083 | |
dc.description.abstract | The composition of ischemic stroke thrombi has gained an increasing amount of interest in recent years. The implementation of endovascular procedures in standard stroke care has granted researchers the unique opportunity to examine patient thrombus material. Increasing evidence indicates that stroke thrombi are complex and heterogenous, consisting of various biochemical (eg, fibrin, von Willebrand Factor, and neutrophil extracellular traps) and cellular (eg, red blood cells, platelets, leukocytes, and bacteria) components. This complex composition may explain therapeutic limitations and also offer novel insights in several aspects of stroke management. Better understanding of thrombus characteristics could, therefore, potentially lead to improvements in the management of patients with stroke. In this review, we provide a comprehensive overview of the lessons learned by examining stroke thrombus composition after endovascular thrombectomy and its potential relevance for thrombectomy success rates, thrombolysis, clinical outcomes, stroke etiology, and radiological imaging. | en_IE |
dc.description.sponsorship | This work was supported by research grants to S.F.D.M. from the Fonds voor Wetenschappelijk
Onderzoek – Vlaanderen (FWO) (research grants G0A8613, G078517, 1509216N and G0E7620N), the
KU Leuven (OT/14/099, ISP/14/02L2 and PDM/20/147), the Queen Elisabeth Medical Foundation and
by the European Union's Horizon 2020 Research and Innovation Program INSIST under grant
agreement No 777072. W.B received funding from the National Institutes of Health Grant
1R01NS105853-01. K.M.D. received funding from Science Foundation Ireland, funding from Cerenovus
and funding from Sensome. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Lippincott, Williams & Wilkins | en_IE |
dc.relation.ispartof | Stroke | en |
dc.rights | CC BY-NC-ND 3.0 IE | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Stroke Thrombus | en_IE |
dc.subject | Composition | en_IE |
dc.subject | Thrombectomy | en_IE |
dc.title | Studying stroke thrombus composition after thrombectomy: What can we learn? | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2022-03-16T09:00:54Z | |
dc.identifier.doi | 10.1161/STROKEAHA.121.034289 | |
dc.local.publishedsource | https://doi.org/10.1161/STROKEAHA.121.034289 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | Horizon 2020 | en_IE |
dc.contributor.funder | Fonds voor Wetenschappelijk Onderzoek – Vlaanderen | en_IE |
dc.contributor.funder | Queen Elisabeth Medical Foundation | en_IE |
dc.contributor.funder | National Institutes of Health | en_IE |
dc.contributor.funder | Science Foundation Ireland | en_IE |
dc.internal.rssid | 27796226 | |
dc.local.contact | Karen Doyle, Dept. Of Physiology, Human Biology Building, Nui Galway. 3665 Email: karen.doyle@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | ACCEPTED | |
dcterms.project | info:eu-repo/grantAgreement/EC/H2020::RIA/777072/EU/IN-Silico trials for treatment of acute Ischemic STroke/INSIST | en_IE |
nui.item.downloads | 79 | |