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Mechanisms of osteocyte stimulation in osteoporosis
(Elsevier, 2016-05-10)
Experimental studies have shown that primary osteoporosis' caused by oestrogen deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular ...
Experimental mechanical testing of Poly (l-Lactide) (PLLA) to facilitate pre-degradation characteristics for application in cardiovascular stenting
(Elsevier, 2016-07-19)
Next-generation stents made from Biodegradable Polymers (BPs) aim to address the long-term risks (i.e. late restenosis and in-stent thrombosis) associated with both Bare Metal Stents and Drug Eluting Stents, whilst aiming ...
Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures
(Springer Verlag, 2016-06)
Recent studies have shown that mechanical stimulation, in the form of fluid perfusion and mechanical compression, can enhance osteogenic differentiation of mesenchymal stem cells and bone cells within tissue engineering ...
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
(AO Research Institute Davos, 2016-05-26)
Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ...