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dc.contributor.authorElliott, Marken
dc.date.accessioned2011-01-28T13:23:00Zen
dc.date.available2011-01-28T13:23:00Zen
dc.date.issued2006en
dc.identifier.citationElliott, M., Giersch, A., & Seifert, D. (2006). Some facilitatory effects of lorazepam on dynamic visual binding. Psychopharmacology, 184(2), 229-238.en
dc.identifier.issn0264-3294en
dc.identifier.urihttp://hdl.handle.net/10379/1575en
dc.description.abstractRationale: The benzodiazepine lorazepam enhances the potential for inhibitory (GABAA) synapses in the cortex to stabilize postsynaptic, excitatory activity by synchronizing discharge rates at frequencies of around 40 Hz. Treatment with lorazepam also affects contour integration processes, suggesting that GABAA-mediated synchronization plays a role in visuospatial organization. This conclusion is supported by other physiological studies that link visual feature integration with neuronal synchronization. Objectives: One experiment was conducted to assess variations in dynamic figural priming as a result of lorazepam administration. Methods: Observers were presented a modified version of a figural priming paradigm designed to investigate the effects of dynamic synchronization on visual feature integration. The priming paradigm consisted of premask crosses presented in a square arrangement within the same phase of a multiphase premask matrix oscillating at 40 Hz. Observers responded to a subsequently presented target square. The modification consisted of line elements presented at various distances relative to the unspecified extension of the lines making up the premask crosses. It was expected that priming effects would be enhanced for lines terminating close to the unspecified extension but only following administration of lorazepam. Results: As anticipated, priming was enhanced substantially when the premask crosses flickered around static lines that terminated adjacent to the unspecified extension between the premask crosses. This effect was maximal following treatment with lorazepam. Conclusions: This finding supports the idea that GABAA-enhanced inhibitory synchronization mediates continuity coding during early visual processing.en
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherSpringeren
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectPsychologyen
dc.subjectLorazepamen
dc.subjectDiazepamen
dc.subjectBenzodiazepineen
dc.subjectVisual bindingen
dc.subjectSynchronizationen
dc.subjectTemporal factorsen
dc.titleSome facilitatory effects of lorazepam on dynamic visual bindingen
dc.typeArticleen
dc.local.publishedsourcehttp://dx.doi.org/10.1007/s00213-005-0242-xen
dc.description.peer-reviewedpeer-revieweden
dc.contributor.funderUniversity Hospital of Strasbourgen
dc.contributor.funderDeutsche Forschungsgemeinschaft project grant # EL 248/1-1en
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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