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Now showing items 11-14 of 14
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
(NUI Galway, 2018-12-14)
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ...
Regulation of fear, anxiety and cognition in the presence or absence of pain by peroxisome proliferator-activated receptors
(NUI Galway, 2019-06-07)
Fear/anxiety and pain modulate one another reciprocally, but the neurobiological mechanisms that underlie this interaction are not completely understood. Fear-conditioned analgesia (FCA) is pain suppression upon exposure ...
Novel approaches to the understanding and treatment of postoperative pain
(NUI Galway, 2019-12-06)
Postoperative pain constitutes a significant medical need. Greater understanding of the mechanisms will allow for more effective treatments. The endogenous cannabinoid (endocannabinoid) and opioid systems play a key role ...
Optogenetic investigations into the role of glutamatergic neurons of the anterior cingulate cortex in sensory and affective components of pain
(NUI Galway, 2019-11-15)
Pain consists of sensory-discriminative and affective-motivational components, which can share a reciprocal relationship. The anterior cingulate cortex (ACC) plays an important role in top-down control and the affective ...