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Implications of histone H2AX abundance in breast cancer
(NUI Galway, 2019-12-09)
Histones are responsible for the packaging of DNA into a eukaryotic cell nucleus, and the H2A variant H2AX plays an important role in the DNA damage response (DDR). The phosphorylated form of H2AX, known as γH2AX, has been ...
Regulation of emotion and cholinergic system connectivity in bipolar disorder
(NUI Galway, 2019-10-04)
Background: The human brain comprises distributed cortico-subcortical regions that are structurally and functionally connected into a network that is known as the human connectome. Understanding how connections between ...