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Urothelial carcinoma: Molecular profiling and potential application in clinical practice
(NUI Galway, 2020-02-19)
Urothelial Carcinoma: Molecular Profiling & Potential Application in Clinical Practice
Abstract
Introduction: Urothelial carcinoma is characterised by a tendency to recurrence and risk of progression that necessitates ...
Diagnostic insights from twenty years of bilateral inferior petrosal sinus sampling for Cushings Disease at Mayo Clinic (1998-2018)
(NUI Galway, 2020-03-02)
Pituitary-dependent Cushing syndrome (CS), referred to herein as Cushing Disease (CD), is the most common cause of endogenous CS. The challenge for diagnosing CD includes difficulty identifying the often small pituitary ...
Exploration of the opioidergic system in the olfactory bulbectomized rat model of depression
(NUI Galway, 2020-02-27)
In recent years, there has been renewed interest in targeting the central opioid system as a novel strategy for the treatment of psychiatric disorders such as depression, due to its involvement in the regulation of mood, ...
The potential of GDF5-functionalised collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2020-03-05)
Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ...
The role of the endogenous opioid system in hyperalgesia associated with negative affect
(NUI Galway, 2020-02-26)
Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ...