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Fabrication of biomimetic electrodes by laser processing and two photon lithography
(NUI Galway, 2020-06-07)
The brain machine interface BMI describes a group of technologies capable of communicating with excitable nervous tissue within the central nervous system (CNS). BMI’s have seen major advances in recent years, but these ...
Porcine peritoneum: A multifunctional xenograft for a diverse range of clinical indications
(NUI Galway, 2020-12-18)
Decellularised xenografts are an inherent component of regenerative medicine. Their preserved structure, mechanical integrity and biofunctional composition have well established them in reparative medicine for a diverse ...
Estrogen deficiency alters the mechanobiological responses of osteoblasts and osteocytes
(NUI Galway, 2020-07-03)
Osteoporosis is most commonly manifested following menopause when estrogen
production is deficient and, as a result, bone loss and changes in bone composition
occur leading to bone fractures. Estrogen inhibits bone ...
Estrogen withdrawal in osteocytes results in altered integrin function, primary cilium elongation, and increased pro-osteoclastogenic signalling
(NUI Galway, 2020-06-28)
Osteocytes are the main mechanosensitive cells within bone. They detect changes in the mechanical environment and transduce them into biochemical responses (RANKL, OPG, and sclerostin) that regulate bone remodelling by ...
Thrombus analogue material: Mechanical characterisation and use in in-vitro modelling of acute ischemic stroke treatment
(NUI Galway, 2020-06-03)
Acute ischemic stroke (AIS), which accounts for approximately 85% of all strokes globally, is among the leading causes of death and long-term disability. It occurs when a blood clot causes an occlusion in a blood vessel, ...
Macromolecular crowding alone or in combination with other in vitro microenvironment modulators to maintain tenogenic phenotype in vitro
(NUI Galway, 2020-07-15)
Tendon injuries are very common among the different musculoskeletal disorders affecting millions of people annually. Given that current treatments have failed to restore injured tendons to the prior to injury state, ...
Computational modelling of the degradation of poly-L-lactide for a bioresorbable polymeric stent
(NUI Galway, 2020-05-08)
The interest in biodegradable polymers for the design of bioresorbable stents, temporary vascular scaffolds designed to restore patency to obstructed vessels, has witnessed a dramatic growth over the last ten to fifteen ...
Integrated proteomic and systems biology approach to understanding injured spinal cord pathophysiology and repair
(NUI Galway, 2020-03-05)
Spinal cord injury (SCI) is a severe neurological condition. There are currently no effective treatment options to restore function following SCI. The major obstacle to developing effective therapies is the fragmented ...