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Genetic determinants of disease characteristics of inflammatory bowel disease and diverticulitis
(2015-05-05)
Background: Inflammatory Bowel Disease (IBD) is a complex, multigenic disease in which both the innate and adaptive immune systems play a strong role. Although over 40 microbes including bacteria, viruses and yeasts and ...
Phenotypic and functional heterogeneity of intermediate monocytes in healthy adults.
(2015-09-30)
Human blood monocytes are currently classified into three subsets: CD14++CD16- “Classical”, CD14++CD16+ “Intermediate” and CD14+CD16++ “Non-Classical”. Distinct functional differences between Classical and Non-Classical ...
Medical student selection: a mixed methods study
(2015-09-29)
Selection to medicine is widely considered the single most important assessment of a doctor's medical career. It is a key deciding factor in the composition of the medical workforce. Selectors have a social responsibility ...
Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype
(2015-11-05)
Prostate cancer is the second most commonly diagnosed cancer, and ranked third in the causes of death from cancer in Irish men. Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 ...
Topics in cocyclic development of pairwise combinatorial designs
(2015-10-14)
This thesis is a compilation of results dealing with cocyclic development of pairwise combinatorial designs. Motivated by a classification of the indexing and extension groups of the Paley Hadamard matrices due to de ...
The glycosylation signature of human urinary extracellular vesicles
(2015-12-22)
Cells of virtually all organs and tissues are known to release large numbers of subcellular particles called extracellular vesicles (EVs) into bodily fluids such as blood and urine. There has been a growing interest in ...
An analysis of the health risks associated with international travel
(2015-01-28)
This thesis, submitted for the award of a doctoral degree in Medicine, represents an attempt to collate all of my original research projects in travel medicine completed at NUI Galway. Chapter 1 presents four projects ...
Preclinical assessment of the novel compound EL102 in prostate cancer
(2015-03-31)
Prostate cancer remains a growing problem for the male population, globally. Though there have been clinical advances in recent years, there still remains a need to develop drugs that can slow or stop progression beyond ...
The effects of anti-TNFα antibody therapy on peripheral blood mononuclear cells in patients with inflammatory bowel disease
(2015-09-30)
Monocytes, recently classified as CD14++CD16- (classical), CD14++CD16+ (intermediate) and CD14dimCD16++ (non-classical) are considered to play a role in the pathogenesis of inflammatory bowel diseases (IBD). Anti-tumor ...
The prevalence of abnormal glucose tolerance up to 5 years after an index pregnancy complicated by gestational diabetes defined using International Association of Diabetes and Pregnancy Study Groups criteria
(2015-09-25)
Introduction
Gestational diabetes (GDM) is associated with an increased future risk of type 2 diabetes, but the risk among women diagnosed with the International Association of Diabetes and Pregnancy Study Groups (IADPSG) ...