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The role of sialylation in stromal cell-mediated immunosuppression in the colorectal tumour microenvironment
(NUI Galway, 2023-04-19)
Immunosuppressive tumour microenvironments (TME) inhibit the effectiveness of many
immunotherapies. The hypersialylation of cancer cells contributes significantly to this
suppressive environment, aiding in tumour immune ...
Advanced therapies in pancreatic islet transplantation for type 1 diabetes mellitus
(NUI Galway, 2023-03-14)
Type 1 diabetes mellitus is an autoimmune condition whereby β-cells are destroyed by
the immune system causing the lack/absence of insulin production and resultant
hyperglycaemia. Pancreatic islet transplantation is ...
The role of microRNAs in muscle wasting during ageing and disease
(NUI Galway, 2023-05-23)
Sarcopenia is age-related muscle loss and management is complex. The mechanisms
underpinning age-related decline in muscle health include defective muscle
regeneration and deterioration of neuromuscular junctions. ...
Novel computational functional assessment of coronary stenosis and its clinical applications in predicting and evaluating procedural results
(NUI Galway, 2023-06-13)
Coronary angiography has limited efficacy in identifying patients with suboptimal
results after percutaneous coronary intervention (PCI). Immediate post-procedural
functional assessment, including fractional flow reserve ...
Novel computational biomechanics for the assessment of coronary plaque vulnerability and its clinical implications
(NUI Galway, 2023-06-12)
Acute coronary syndromes (ACS) continue to be one of the major causes of mortality
around the world. Accumulating evidence indicates that thrombosis plays a critical role
in the pathogenesis of ACS. Autopsy studies have ...
Vascular plasticity and target for therapy in Duchenne muscular dystrophy
(NUI Galway, 2023-06-13)
Angiogenesis is the growth of new blood vessels from pre-existing vessels, necessary for the
growth and maintenance of homeostasis. Duchenne muscular dystrophy (DMD) is a
debilitating disease of the musculoskeletal ...
Extracellular vesicle encapsulated microRNAs and breast cancer
(NUI Galway, 2023-02-24)
Breast cancer is the most prevalent cancer among women worldwide. There
is a clear need for earlier detection methods and more personalised treatments.
Extracellular vesicle encapsulated microRNA (EV-miR) provide novel ...
Characterisation and analysis of Memory T-cells in COVID-19 patient sample
(NUI Galway, 2023-08-08)
Background: Immunological memory is the key to long-term protection against disease. It is
the hallmark of adaptive immunity which facilitates an accelerated and enhanced immune
response against a pathogen encountered ...
Sleep and neurovascular disease
(NUI Galway, 2023-09-25)
Sleep has a complex relationship with human health. Impairments in sleep represent a
common, potentially modifiable risk factor for incident stroke, and functional recovery after
acute stroke. Research on the association ...
Effect of glycaemic excursions on QT interval in diabetes patients
(NUI Galway, 2023-09-19)
Glucose excursions in Diabetes Mellitus patients are associated with increased risk of
cardiac morbidity and mortality (Kaul, Tarr, Ahmad, Kohner, & Chibber, 2013). With
the evidence from several clinical trials, it ...