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Adaptive clinical trials of sodium lowering in chronic kidney disease and dialysis: Analytic and methodologic challenges
(NUI Galway, 2022-04-24)
The incidence and prevalence of kidney failure requiring dialysis is rising. Patients receiving dialysis are at increased cardiovascular risk, compared to the general population. Hypertension due to sodium and volume excess ...
Importance of the caregiver in lifestyle interventions for cognitive impairment
(NUI Galway, 2022-04-11)
Lifestyle risk factors have been identified as key targets for dementia prevention strategies, with most clinical trials targeting individual-level interventions. However, many lifestyle behaviours are known to cluster ...
Investigation of the role of mesenchymal stromal cells in modulating macrophage phenotype and function in the colorectal tumour microenvironment
(NUI Galway, 2022-06-28)
Colorectal cancer (CRC) is the third most commonly occurring cancer. While there have been improvements in treatment options for patients, it remains the second leading cause of cancer-related deaths worldwide. CRC develops ...
Molecular profiling and genomic substratification to personalise therapeutic decision making in cancer
(NUI Galway, 2022-08-16)
Breast cancer management recognises that the unique genetic expression profiles of each cancer enables substratification into clinically and therapeutically distinct molecular subgroups. There are pragmatic ways of ...
Advances in the management and treatment algorithms for anterior shoulder instability
(NUI Galway, 2022-04-28)
Anterior shoulder instability is a common clinical problem, with a reported incidence ranging from 8 to 25 per 100,000 person years in the general population, with higher rates seen
1-3
in athletic populations.
However, ...
Evaluation of antibiotic resistant enterobacterales in the Irish environment
(NUI Galway, 2022-10-03)
Antibiotic resistance represents a significant public health challenge of global magnitude. In particular, infections caused by extended spectrum beta-lactamase (ESBL) and carbapenemase producing Enterobacterales (CPE) ...
Human induced pluripotent stem cells as an in vitro model for autism spectrum disorder
(NUI Galway, 2022-08-23)
Autism spectrum disorders (ASD) are neurodevelopmental disorders which encompass a wide range of symptoms, including intellectual disability and delayed development, while the phenotype can range from mild to severe. Genetic ...
Development of a mesenchymal stromal cell / collagen scaffold product for treatment of diabetic wounds
(NUI Galway, 2022-08-23)
Foot ulceration is a major complication of diabetes mellitus, which results in significant
human suffering and a major burden on healthcare systems. Mesenchymal stromal cells
(MSCs) emerged as a promising therapeutic ...
Plasma glycated CD59, a novel biomarker for the prediction, diagnosis, and follow-up of women with gestational diabetes
(NUI Galway, 2022-12-06)
The prevalence of gestational diabetes (GDM) is rising worldwide. Plasma glycated CD59 (pGCD59) is an emerging biomarker for the detection of hyperglycaemia. The aim of this study was to explore the ability of pGCD59 to ...
Application of CRISPR/Cas9 gene editing to target Neuronal Interleukin-16 a novel protein involved in osteoarthritis progression
(NUI Galway, 2022-09-07)
Osteoarthritis (OA) is a debilitating joint disease affecting an increasing proportion of the elderly population worldwide annually. Current treatments for the disease are symptomatic with management of pain and side effects ...