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Now showing items 11-18 of 18
The role of novel biomarkers in addressing the burden of chronic kidney disease in diabetes mellitus
(NUI Galway, 2022-10-06)
Kidney disease due to diabetes (Diabetic Kidney Disease (DKD)) is the leading cause of chronic kidney disease worldwide. It is an underappreciated, often under-recognised component of the overall burden of diabetes. People ...
Human stem cell modelling for heart disease of long QT syndrome
(NUI Galway, 2022-04-29)
Sudden cardiac death (SCD) in otherwise healthy young people is a public health priority. Long QT syndrome (LQTS) is the commonest life-threatening cardiac arrhythmia contributing to SCD under 40 years old with an estimated ...
In vitro, pre-clinical and commercial evaluation of a novel xeno- and serum-free culture system for production of human bone marrow derived mesenchymal stem cells for bone regeneration
(2016-10-21)
The therapeutic potential of mesenchymal stem cells (MSCs) is recognised in treating a wide range of debilitating diseases. For clinical-scale manufacturing, serum-free and xenogenic-free media formulations have been ...
Human stem cell modeling for amyotrophic lateral sclerosis
(NUI Galway, 2022-09-28)
Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons (MNs). Most ALS cases are sporadic, with no family history or known genetic ...
Immunogenicity of allogeneic mesenchymal stem cells
(2016-10-20)
Allogeneic mesenchymal stem cells (allo-MSC) are a promising “off-the-shelf” therapy and are often cited as failing to elicit anti-donor immune responses. Intra-muscular (IM) administration may be the optimal route for ...
Enhancing the immunomodulatory capacity and therapeutic potential of mesenchymal stromal cell-derived small extracellular vesicles through cytokine licensing
(NUI Galway, 2023-09-12)
The immunomodulatory capacity of mesenchymal stromal cells (MSCs) is well
established, and is being explored as a cellular therapy for the treatment of various
inflammatory-based conditions. In recent years, the role of ...
Influence of tissue source on the therapeutic potential of mesenchymal stromal cells
(NUI Galway, 2023-05-11)
Advanced therapy medicinal products (ATMPs) offer revolutionary new prospects for the
treatment of conditions of unmet medical need. Among them, Mesenchymal Stromal Cells
(MSCs) have emerged as promising candidates for ...
Novel high-resolution imaging modalities for monitoring in vitro models of cartilage degeneration and mesenchymal stem cell therapy in osteoarthritis
(NUI Galway, 2023-06-20)
Osteoarthritis (OA) is a chronic disease of synovial joints characterized by progressive
degeneration of articular cartilage causing pain and disability in millions of people worldwide.
Current imaging systems used for ...